Temperature/pH Dual-Responsive Hydrogels: Research Progress in Preparation Methods, Structural Design Strategies and
Sisi Wang1, Gang Wang1,2, Xuefei Liu1,2
1School of Physics and Electronic Science, Guizhou Normal University, Guiyang 550025, China.
Gels (Basel, Switzerland)
|May 27, 2026
Summary
Temperature/pH dual-responsive hydrogels are smart materials with reversible changes. This review details their preparation, design, and biomedical uses in drug delivery, tissue engineering, and diagnostics.
Area of Science:
- Materials Science
- Biomedical Engineering
- Polymer Chemistry
Background:
- Smart hydrogels respond to environmental stimuli.
- Temperature/pH dual-responsive hydrogels offer advanced functionalities.
- These materials are crucial for biomedical applications.
Purpose of the Study:
- To systematically review preparation methods, structural designs, and biomedical applications of temperature/pH dual-responsive hydrogels.
- To provide a comprehensive overview of recent advancements in the field.
- To identify challenges and future research directions.
Main Methods:
- Chemical, physical, and hybrid crosslinking for hydrogel preparation.
- Fabrication of microsphere, core-shell, and layered structures.
- Review of literature on hydrogel synthesis and applications.
Main Results:
- Detailed comparison of different preparation techniques.
- Elucidation of various structural design strategies and fabrication processes.
- Summary of progress in drug delivery, cancer therapy, biosensing, tissue engineering, and wound healing.
Conclusions:
- Temperature/pH dual-responsive hydrogels show significant promise in diverse biomedical fields.
- Further research is needed to address current challenges and unlock future potential.
- This review consolidates knowledge for researchers in smart materials and biomedical applications.
