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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...

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Related Experiment Video

Updated: May 28, 2026

Exploring the Pharmacological Action and Molecular Mechanism of Salidroside in Inhibiting MCF-7 Cell Proliferation and Migration
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Exploring the Pharmacological Action and Molecular Mechanism of Salidroside in Inhibiting MCF-7 Cell Proliferation and Migration

Published on: June 9, 2023

Plant-Derived Bioactive Compounds and Their Therapeutic Potential in Cancer.

Martina Šemeláková1, Terézia Hudáková1, Peter Solár1

  • 1Department of Medical Biology, Faculty of Medicine, Pavol Jozef Šafárik University in Košice, 040 11 Košice, Slovakia.

International Journal of Molecular Sciences
|May 27, 2026
PubMed
Summary

Plant compounds are vital in cancer therapy, offering established and new treatments. This review classifies anticancer phytochemicals by development status and molecular targets, aiding precision oncology.

Keywords:
bioavailabilitycancer therapymolecular mechanismphytochemicalsplant-derived bioactive compounds

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Last Updated: May 28, 2026

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Published on: January 19, 2022

Area of Science:

  • Pharmacology
  • Phytochemistry
  • Oncology

Background:

  • Plant-derived bioactive compounds are crucial in modern cancer treatment.
  • They offer a rich source of molecules with significant clinical anticancer activity.

Purpose of the Study:

  • To classify plant-derived anticancer compounds based on clinical development and molecular mechanisms.
  • To highlight multitarget phytochemicals and their roles in cancer hallmarks.
  • To discuss translational challenges and nano-delivery systems for enhanced efficacy.

Main Methods:

  • Literature review and classification of plant-derived anticancer agents.
  • Analysis of molecular mechanisms targeting cancer hallmarks.
  • Discussion of clinical development status and delivery system advancements.

Main Results:

  • Classification distinguishes established agents (taxanes, vinca alkaloids) from investigational phytochemicals (polyphenols, flavonoids, terpenoids, alkaloids).
  • Phytochemicals target microtubule dynamics, topoisomerases, signaling pathways (PI3K/Akt, NF-κB, JAK/STAT, MAPK), and angiogenesis.
  • Multitarget phytochemicals show promise in inducing apoptosis and epigenetic reprogramming.

Conclusions:

  • Plant-derived compounds remain highly relevant in oncology.
  • Understanding their mechanisms and development status supports integration into precision cancer therapy.
  • Advances in nano-delivery systems can overcome bioavailability challenges and reduce toxicity.