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08:23
Visualization of Bacterial Resistance using Fluorescent Antibiotic Probes
Published on: March 2, 2020
Iodine-Based Coordination Compounds: A Strategy Toward Antibiotic Potentiation
Daniil Shepilov1, Dana Askarova1, Anar Seisembekova1
1JSC Scientific Center for Anti-Infectious Drugs, Almaty 050060, Kazakhstan.
International Journal of Molecular Sciences
|May 27, 2026
Summary
New iodine-containing coordination complexes with sodium sulfadimidine and gentamicin sulfate show potent antimicrobial and antiviral activities. These compounds, KC-246 and KC-248, exhibit low cytotoxicity, offering promising therapeutic potential against resistant infections.
Area of Science:
- Medicinal Chemistry
- Antimicrobial Research
- Virology
Background:
- Rising antibiotic resistance and novel pathogens necessitate innovative therapeutic strategies.
- Combined therapeutic agents are crucial for combating infectious diseases effectively.
- Iodine-based coordination complexes offer a novel approach to antimicrobial and antiviral drug development.
Purpose of the Study:
- To synthesize and characterize novel iodine-containing coordination complexes with antibiotics.
- To evaluate the physicochemical properties, cytotoxicity, and biological activities of these compounds.
- To investigate the potential of these complexes as combined therapeutic agents against bacterial, fungal, and viral infections.
Main Methods:
- Synthesis of iodine coordination complexes with sodium sulfadimidine and gentamicin sulfate.
- Physicochemical characterization using capillary electrophoresis and UV spectroscopy.
- Assessment of cytotoxicity, antimicrobial activity (Minimum Bactericidal Concentration), and antiviral activity against herpes simplex virus and influenza A.
Main Results:
- Two stable compounds, KC-246 and KC-248, were successfully synthesized.
- Compounds demonstrated significant virus-inhibitory activity against herpes simplex virus and influenza A at low cytotoxicity levels (0.018-0.106 mg/mL).
- Broad-spectrum antimicrobial activity was observed against Staphylococcaceae, Pseudomonadaceae, Enterobacteriaceae, Enterococcaceae, and yeast-like fungi, with MBCs ranging from 0.198 to 2.093 µg/mL.
Conclusions:
- The synthesized iodine coordination complexes, KC-246 and KC-248, possess significant antimicrobial and antiviral properties.
- These compounds exhibit a favorable safety profile with low cytotoxicity, making them promising candidates for new anti-infective therapies.
- The study highlights the potential of iodine-based coordination complexes as effective combined therapeutic agents against a range of pathogens.
Keywords:
active pharmaceutical substancesdrug–drug synergyiodine-containing compoundsnovel antimicrobial adjuvantsresistance mitigationMore Related Videos
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