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Genetic Variations in the Fibronectin 1 Gene (FN1) and Risk of Female Reproductive Cancers-A Preliminary Study
Piotr Pawlik1, Grażyna Kurzawińska2,3, Marcin Ożarowski4
1Department of Obstetrics and Gynecology, District Public Hospital in Poznan, Juraszów 7/19, 60-479 Poznan, Poland.
International Journal of Molecular Sciences
|May 27, 2026
Summary
Two single-nucleotide variants (SNVs) in the FN1 gene may slightly increase the risk of gynecological cancers, particularly ovarian cancer. Further research is needed to confirm these findings in larger patient groups.
Area of Science:
- Genetics
- Oncology
- Molecular Biology
Background:
- The FN1 gene encodes proteins crucial for the extracellular matrix (ECM) and tumor microenvironment (TME).
- Genetic variations in FN1 may influence susceptibility to gynecological cancers.
Purpose of the Study:
- To investigate the association between five single-nucleotide variants (SNVs) in the FN1 gene and the risk of cervical, uterine, and ovarian cancers.
- To identify specific FN1 variants or haplotypes linked to increased risk in female reproductive system cancers.
Main Methods:
- Genomic DNA from 208 female cancer patients (cervical, uterine, ovarian) and 208 controls was analyzed.
- Five intronic SNVs of the FN1 gene were genotyped using Polymerase Chain Reaction/Restriction Fragment Length Polymorphism (PCR/RFLP).
- Statistical analyses included dominant, log-additive models, and haplotype analysis to assess risk associations.
Main Results:
- Two FN1 variants, rs6725958 and rs1968510, showed a potential association with increased overall gynecological cancer risk (p ≤ 0.048).
- Ovarian cancer showed a notable association with rs1968510 (p ≤ 0.016) and rs6725958 (p ≤ 0.070) in specific models.
- The AGATC haplotype, containing minor alleles for rs35343655 and rs6725958, was significantly more frequent in the overall gynecological cancer group (p = 0.0036) and individual cancer types.
Conclusions:
- Preliminary evidence suggests that specific FN1 variants (rs6725958, rs1968510) and the AGATC haplotype may be associated with an increased risk of female reproductive system cancers, especially ovarian cancer.
- These genetic associations require validation in larger, independent cohorts.
- Further functional studies are warranted to elucidate the biological mechanisms underlying these observed associations.
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