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Mechanisms Involved in Pathological Succinate-Mediated Signaling
Bismarck Bernabe-Yepes1, Cecilia Zazueta1
1Departamento de Biomedicina Cardiovascular, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano No. 1 Tlalpan, Mexico City 14080, Mexico.
International Journal of Molecular Sciences
|May 27, 2026
Summary
Extracellular succinate acts as a signaling molecule via succinate receptor 1 (SUCNR1). Its signaling pathways show context-dependent effects, influencing inflammation and metabolic regulation in various diseases.
Area of Science:
- Biochemistry
- Cellular Biology
- Metabolic Regulation
Background:
- Succinate is a Krebs cycle intermediate with emerging roles beyond energy metabolism.
- Extracellular succinate functions as a signaling molecule through succinate receptor 1 (SUCNR1).
- SUCNR1 signaling exhibits significant heterogeneity across different pathological contexts.
Purpose of the Study:
- To comprehensively analyze SUCNR1 signaling pathways activated by succinate.
- To explore the context-dependent nature of succinate-SUCNR1 interactions.
- To evaluate the therapeutic potential of modulating succinate signaling in diseases.
Main Methods:
- Literature review of studies on succinate and SUCNR1.
- Analysis of signaling pathways involved in succinate-SUCNR1 interactions.
- Examination of biological outcomes in various pathological conditions.
Main Results:
- Succinate-SUCNR1 signaling influences inflammation, cellular signaling, and metabolic regulation.
- Biological outcomes of SUCNR1 activation are varied and context-dependent.
- Heterogeneity in SUCNR1 signaling contributes to disease progression.
Conclusions:
- Succinate's role extends beyond metabolism, impacting disease pathogenesis via SUCNR1.
- Understanding the context-dependent nature of succinate signaling is crucial.
- Targeting succinate-SUCNR1 pathways may offer therapeutic strategies for various diseases.
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