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Related Experiment Video

Updated: May 28, 2026

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
09:08

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Published on: October 14, 2021

Sex-Specific Transcriptomic Profiles in Psoriatic Lesions: A Large-Scale Integrative Study.

Edia Stemmer1, Liat Anabel Sinberger1, Tair Lax1

  • 1Department of Molecular Biology, Ariel University, Ariel 40700, Israel.

International Journal of Molecular Sciences
|May 27, 2026
PubMed
Summary

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This summary is machine-generated.

This study reveals significant sex-specific molecular differences in psoriasis, identifying distinct gene expression patterns and cellular pathways in males and females. These findings offer new insights into psoriasis pathogenesis and potential sex-tailored treatments.

Area of Science:

  • Dermatology
  • Immunology
  • Genomics

Background:

  • Psoriasis is a chronic inflammatory skin condition with known gender-based variations in severity and treatment outcomes.
  • Despite extensive research into psoriasis mechanisms, sex-specific molecular differences remain largely uncharacterized.

Purpose of the Study:

  • To investigate sex-specific transcriptomic differences in lesional psoriasis skin.
  • To identify molecular pathways and upstream regulators that differ between male and female psoriasis patients.

Main Methods:

  • Comprehensive analysis of transcriptomic data from lesional psoriasis skin and healthy controls in male and female cohorts.
  • Identification of overlapping and sex-specific differentially expressed genes (DEGs).
  • Upstream regulator analysis to identify sex-specific drivers.
Keywords:
IL-17 signalingbiomarkersinflammationpathogenesispsoriasissex-specific expression

Related Experiment Videos

Last Updated: May 28, 2026

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from S&#233;zary Syndrome Patients for Transcriptomic Profiling
09:08

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Published on: October 14, 2021

Main Results:

  • 2760 overlapping DEGs were identified, with shared pathways including IL-17 signaling and Th17 differentiation.
  • Male-enriched pathways included PI3K-Akt signaling and chemokine receptor activity.
  • Female-enriched pathways included glycolysis and AHR-NRF2 signaling. Sex-specific upstream regulators and differences in Regulatory T cells (Tregs) and neutrophil abundance were also noted.

Conclusions:

  • Significant sex-associated molecular and cellular disparities exist in psoriasis.
  • These findings highlight potential sex-specific mechanisms influencing disease manifestation and treatment response.
  • This exploratory study provides a foundation for future research into sex-specific psoriasis therapies.