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Abundance of Inflammatory Response Genes Among Cardiovascular Disease and Ischemic Stroke Genes

Gennady V Khvorykh1, Ivan B Filippenkov1, Andrey V Khrunin1

  • 1Laboratory of Human Molecular Genetics, National Research Centre "Kurchatov Institute", Kurchatov Sq. 1, Moscow 123182, Russia.

International Journal of Molecular Sciences
|May 27, 2026
PubMed

Insights

This study identified 1285 inflammatory genes involved in cardiovascular disease and ischemic stroke, highlighting NFKB1 and RELA. These findings are crucial for developing new anti-inflammatory therapies for stroke.

Area of Science:

  • Molecular Biology
  • Genetics
  • Immunology

Background:

  • Inflammation is central to cardiovascular disease and ischemic stroke pathogenesis.
  • The precise number and identity of inflammatory genes involved remain incompletely understood.
  • Identifying these genes is critical for therapeutic development.

Purpose of the Study:

  • To identify and analyze inflammatory genes associated with cardiovascular disease and ischemic stroke.
  • To compile a comprehensive list of inflammation-related genes relevant to these conditions.
  • To discover potential therapeutic targets for anti-inflammatory strategies.

Main Methods:

  • Retrieved human gene data for ischemic stroke (N=1177) and cardiovascular disease (N=1756) from DisGeNET.
  • Compiled inflammatory and immune response gene lists from Gene Ontology, NCBI, and Reactome databases.
  • Integrated previously identified rat brain inflammatory genes (N=140) and performed bioinformatics analysis.

Main Results:

  • A combined list of 1285 inflammatory genes relevant to cardiovascular disease and ischemic stroke was generated.
  • NFKB1 and RELA genes showed the highest frequency across multiple inflammatory gene databases.
  • A representative list of key inflammatory genes for ischemic stroke pathogenesis was established.

Conclusions:

  • The study successfully compiled a significant list of inflammatory genes implicated in cardiovascular disease and ischemic stroke.
  • NFKB1 and RELA are identified as highly frequent and potentially critical inflammatory genes.
  • The identified genes offer promising targets for developing novel anti-inflammatory therapeutic strategies for ischemic stroke.

Keywords:
cardiovascular diseasegene expressionhuman genesinflammationischemic strokerat gene orthologuestMCAO

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