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Bat-Inspired Longevity: Immune Damage Management and Nutritional Modulation for Healthy Aging.
Sunmin Park1,2, James W Daily3
1Department of Food and Nutrition, Obesity/Diabetes Research Center, Hoseo University, Asan 31499, Republic of Korea.
International Journal of Molecular Sciences
|May 27, 2026
Summary
Bats exhibit exceptional longevity due to enhanced resilience and damage tolerance, challenging inflammaging theories. Their unique immune strategies offer insights into promoting healthy human aging and longevity through nutritional interventions.
Area of Science:
- Immunology
- Gerontology
- Comparative Biology
Background:
- Bats display remarkable longevity despite high metabolic rates and pathogen exposure, contradicting traditional inflammaging models.
- This longevity is linked to unique immune mechanisms, including damage tolerance and regulated inflammation, rather than heightened immunity.
Purpose of the Study:
- To introduce the Core Longevity State Vector (CLSV-6) as a framework for understanding bat longevity and its implications for human aging.
- To explore nutritional strategies that can shift human immunity towards a bat-like, resilient immunotype.
Main Methods:
- Development of the CLSV-6 framework, integrating six conserved mechanisms: damage tolerance, autophagy-mitophagy, proteostasis, basal immune readiness, inflammasome regulation, and inflammatory resolution.
- Comparative analysis of bat immune strategies and centenarian immune profiles.
- Proposal of functional foods as interventions.
Main Results:
- The CLSV-6 framework links bat immunity to longevity and human healthy aging.
- Bats and centenarians share immune characteristics like reduced NLRP3 inflammasome activation and enhanced resilience.
- Functional foods are suggested to promote a CLSV-6 immunotype in humans.
Conclusions:
- Bat longevity offers a new paradigm for aging research, emphasizing damage containment over immune stimulation.
- The CLSV-6 provides a mechanistic roadmap for nutritional interventions to enhance human immune resilience and promote healthy aging.
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