Related Experiment Video

Updated: May 28, 2026

Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane
05:36

Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane

Published on: February 8, 2020

Natural Products in Clear Cell Renal Cell Carcinoma: Rewiring the VHL-HIF Axis, Metabolic Plasticity, and

Yao-Chou Tsai1,2, Chung-Che Tsai3, Vincent F S Tsai1

  • 1Division of Urology, Department of Surgery, Taipei Tzuchi Hospital, The Buddhist Tzu Chi Medical Foundation, New Taipei City 23142, Taiwan.

International Journal of Molecular Sciences
|May 27, 2026
PubMed

Insights

Natural compounds like curcumin and resveratrol may enhance clear cell renal cell carcinoma (ccRCC) treatment by targeting the VHL-HIF pathway and immune interactions. Further research is needed for clinical application.

Area of Science:

  • Oncology
  • Molecular Biology
  • Natural Products Chemistry

Background:

  • Clear cell renal cell carcinoma (ccRCC) is driven by VHL gene mutations, leading to sustained HIF activation.
  • This pathway regulates key cancer processes including angiogenesis, metabolism, and immune evasion.
  • Current therapies show limited efficacy due to adaptive resistance.

Purpose of the Study:

  • To review the potential of natural products in modulating ccRCC oncogenic pathways.
  • To explore how compounds like curcumin, resveratrol, quercetin, and EGCG impact the VHL-HIF axis.
  • To assess the influence of these natural products on ccRCC's metabolic and immune microenvironment.

Main Methods:

  • Literature review of studies on natural products and ccRCC.
  • Analysis of mechanisms by which selected compounds affect VHL-HIF signaling.
  • Examination of effects on metabolic reprogramming and immune interactions in ccRCC.

Main Results:

  • Natural products modulate the VHL-HIF axis, a key driver in ccRCC.
  • Compounds disrupt metabolic and redox homeostasis within tumor cells.
  • These agents influence tumor-immune system interactions, potentially overcoming resistance.

Conclusions:

  • Natural products show promise in enhancing therapeutic sensitivity for ccRCC.
  • A systems-level approach suggests these compounds can target multiple oncogenic pathways.
  • Clinical validation is necessary to translate these findings into effective ccRCC treatments.
Keywords:
HIFVHLccRCCnatural productstumor microenvironment

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