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Related Experiment Video

Updated: May 28, 2026

Multifractal Spectrum Analysis for Assessing Pulmonary Nodule Malignancy
05:24

Multifractal Spectrum Analysis for Assessing Pulmonary Nodule Malignancy

Published on: January 10, 2025

East-West Disparities in Lung Cancer Screening: Subsolid Nodule Prevalence, Interval Growth, and Decision-Making

Yi-Chi Hung1,2,3, Yun-Ju Wu1, Fu-Zong Wu1,2,4,5

  • 1Department of Radiology, Kaohsiung Veterans General Hospital, Kaohsiung 813414, Taiwan.

Diagnostics (Basel, Switzerland)
|May 27, 2026
PubMed
Summary

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Precision Medicine in Lung Cancer Screening: A Paradigm Shift in Early Detection-Precision Screening for Lung Cancer.

Diagnostics (Basel, Switzerland)·2025

Lung cancer screening effectively reduces mortality in heavy smokers. This review examines key differences in screening rates, nodule management, and overdiagnosis challenges between Eastern and Western countries to optimize strategies.

Area of Science:

  • Pulmonology
  • Oncology
  • Radiology

Background:

  • Lung cancer screening significantly reduces mortality in heavy smokers, supported by trials like the National Lung Screening Trial (NLST) and European studies (NELSON, MILD).
  • Medicare coverage expanded in 2021 to include individuals aged 50-80 with a ≥20 pack-year smoking history, reflecting established screening guidelines.
  • Risk stratification models like Prostate, Lung, Colorectal, and Ovarian (PLCO) are effective for smokers, but research on non-smokers is ongoing.

Purpose of the Study:

  • To review and highlight five critical issues impacting lung cancer screening effectiveness and equity in Eastern and Western countries.
  • To analyze regional variations in screening rates, subsolid nodule (SSN) prevalence and management, and the challenges of overdiagnosis.
  • To emphasize the need for tailored screening approaches considering evolving lung cancer demographics and the balance between early detection and overdiagnosis.
Keywords:
decision makinglung cancer screeningsub-solid nodules

Related Experiment Videos

Last Updated: May 28, 2026

Multifractal Spectrum Analysis for Assessing Pulmonary Nodule Malignancy
05:24

Multifractal Spectrum Analysis for Assessing Pulmonary Nodule Malignancy

Published on: January 10, 2025

Main Methods:

  • Literature review and analysis of existing lung cancer screening trials and guidelines.
  • Comparative analysis of screening practices, policies, and outcomes between Eastern and Western healthcare systems.
  • Examination of data on subsolid nodule (SSN) prevalence, growth characteristics, and management strategies.
  • Review of overdiagnosis concerns and their regional implications.
  • Analysis of microsimulation models predicting future lung cancer trends.

Main Results:

  • Significant disparities exist in lung cancer screening rates globally due to differing healthcare policies and public awareness.
  • Subsolid nodule (SSN) prevalence and growth thresholds vary between Eastern and Western populations, impacting screening strategies and clinical decision-making.
  • Management protocols for SSNs, including follow-up and intervention, differ across regions, affecting patient outcomes.
  • Overdiagnosis presents a critical concern, with unique challenges in each region influenced by screening frequency and healthcare infrastructure.
  • Projections indicate a decrease in smoking-related lung cancer but an increase in non-smoking-related cases, necessitating adaptive screening protocols.

Conclusions:

  • Optimizing lung cancer screening requires addressing regional disparities in screening rates, SSN management, and overdiagnosis.
  • Tailored screening strategies are essential to balance the benefits of early detection with the risks of overdiagnosis, particularly with changing lung cancer etiology.
  • Further research and international collaboration are needed to refine lung cancer screening protocols for diverse populations and evolving epidemiological trends.