Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Early ΔNLR Outperforms Baseline Inflammatory Markers in Predicting Short-Term Outcomes in Sepsis.

Madalina-Ianca Suba1,2, Gheorghe-Bogdan Hogea3,4,5, Varga Norberth-Istvan6

  • 1Methodological and Infectious Diseases Research Center, Faculty of Medicine, "Victor Babeș" University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania.

Diagnostics (Basel, Switzerland)
|May 27, 2026
PubMed

Related Concept Videos

Acute Inflammation III: Local and Systemic Effects01:25

Acute Inflammation III: Local and Systemic Effects

Acute inflammation produces a coordinated set of local and systemic changes that limit injury, eliminate pathogens, and initiate repair. These responses arise within minutes of infection, trauma, or chemical insult and are driven by vascular alterations and leukocyte-derived mediators. When the stimulus resolves, the reaction typically abates within days.Local EffectsAt the site of injury, arteriolar vasodilation increases blood flow, resulting in redness and warmth. Simultaneously, increased...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Social Media Misinformation, Contraceptive Literacy, and Psychological Well-Being Among Romanian Adolescents and Young Adults.

Healthcare (Basel, Switzerland)·2026
Same author

Biologic therapies targeting type 2 inflammation in chronic obstructive pulmonary disease: a systematic review and meta-analysis of randomised controlled trials.

BMJ open respiratory research·2026
Same author

Delayed Radiological Resolution: A Comparative Longitudinal Study of Viral Pneumonia Evolution in Diabetic vs. Non-Diabetic Patients.

Diseases (Basel, Switzerland)·2026
Same author

ATP Bioluminescence Feedback Is Associated with Reduced Residual Hand Contamination Among Healthcare Workers: A Single-Center Before-and-After Study.

Healthcare (Basel, Switzerland)·2026
Same author

Correlation Between CT-Derived Bhalla Score and Lung Ultrasound Score in Adult Patients with Cystic Fibrosis.

Diagnostics (Basel, Switzerland)·2026
Same author

Multimodal Hand Hygiene Interventions and Clinical Healthcare-Associated Infection Outcomes in Acute Care Hospitals: A Systematic Review of Quasi-Experimental Studies.

Journal of clinical medicine·2026
Summary

Early changes in the neutrophil-to-lymphocyte ratio (ΔNLR) offer significant prognostic value for sepsis patients. Monitoring dynamic inflammatory responses improves risk stratification and clinical decision-making for better patient outcomes.

Area of Science:

  • Clinical Medicine
  • Immunology
  • Critical Care Medicine

Background:

  • Sepsis management is challenged by the difficulty in early risk stratification for adverse outcomes.
  • Baseline inflammatory biomarkers have limited prognostic value in sepsis.
  • Dynamic assessment of inflammatory response is needed for improved patient outcomes.

Purpose of the Study:

  • To evaluate the prognostic value of early changes in inflammatory biomarkers, specifically the neutrophil-to-lymphocyte ratio (ΔNLR), in predicting short-term outcomes in sepsis patients.
  • To determine if ΔNLR provides additional prognostic information beyond baseline markers and severity scores.

Main Methods:

  • Retrospective longitudinal observational study of 168 adult sepsis patients.
  • Assessment of inflammatory biomarkers (CRP, procalcitonin, NLR) at admission and 48-72 hours.
Keywords:
NLRSOFA scorecritical caredynamic biomarkersin-hospital mortalityinflammatory biomarkersneutrophil-to-lymphocyte ratioprognosisrisk stratificationsepsis

Related Experiment Videos

  • Analysis of early changes (Δ values) and their association with composite adverse outcomes using logistic regression and ROC curves.

    • Main Results:

    • Patients with adverse outcomes had higher baseline inflammatory markers and severity scores.
    • Early reductions in CRP and NLR were associated with survival; non-survivors had persistently elevated markers.
    • ΔNLR independently predicted in-hospital mortality (OR 0.91) and improved prediction when combined with SOFA score (AUC 0.81).

    Conclusions:

    • Early changes in inflammatory biomarkers, particularly ΔNLR, offer significant prognostic information in sepsis.
    • Dynamic assessment of the immune response enhances early risk stratification.
    • This approach supports individualized clinical decision-making for sepsis management.