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Related Experiment Video

Updated: May 28, 2026

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Published on: February 19, 2021

COVID-19 and Radiological Progression of Multiple Sclerosis.

Hien Quang Nguyen¹, Roham Hadidchi¹, Anna Eligulashvili¹

¹Department of Radiology, Montefiore Health System, Albert Einstein College of Medicine, New York, NY 10461, USA.

Diagnostics (Basel, Switzerland)

|May 27, 2026

Summary

This summary is machine-generated.

COVID-19 infection did not accelerate radiological progression in multiple sclerosis (MS) patients over a two-year period. Further research is needed for severe cases and specific subgroups.

Keywords:

COVID-19 MS progression brain MRI multiple sclerosis neuroimaging

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Last Updated: May 28, 2026

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

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Positron Emission Tomography Imaging for In Vivo Measuring of Myelin Content in the Lysolecithin Rat Model of Multiple Sclerosis

Positron Emission Tomography Imaging for In Vivo Measuring of Myelin Content in the Lysolecithin Rat Model of Multiple Sclerosis

Published on: February 28, 2021

Area of Science:

Neurology
Infectious Diseases
Radiology

Background:

SARS-CoV-2 infection's impact on multiple sclerosis (MS) neuroinflammation and progression remains unclear.
Conflicting previous studies report increased disability or no significant differences post-COVID-19.

Purpose of the Study:

To investigate the association between COVID-19 and accelerated radiological progression in MS patients.
To compare MRI-based markers of disease activity between SARS-CoV-2 positive and negative MS patients.

Main Methods:

Retrospective longitudinal study of 34 SARS-CoV-2 positive (COVID+) and 67 SARS-CoV-2 negative (COVID-) relapsing-remitting MS patients.
Matched patients based on index date, comparing brain MRIs before and after SARS-CoV-2 infection.
Radiologists assessed new/enlarging T2 lesions, T1 gadolinium-enhancing lesions, and brain volume loss.

Main Results:

No significant differences observed between COVID+ and COVID- groups in new lesions (8.8% vs. 9.0%), enlarging lesions (2.9% vs. 6.0%), or T1-enhancing lesions (5.9% vs. 1.5%).
Brain volume loss showed no significant difference between groups (35.3% vs. 47.8%).
All comparisons yielded p > 0.05, indicating no statistically significant association.

Conclusions:

SARS-CoV-2 infection was not associated with accelerated radiological progression in MS patients over a two-year follow-up.
Longer-term studies are necessary to explore potential risks in specific subgroups or severe COVID-19 cases.
Findings suggest COVID-19 may not significantly impact MS radiological activity in the general MS population.