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Related Concept Videos

Microbiota Modulation by Antibiotics01:21

Microbiota Modulation by Antibiotics

Antibiotics have revolutionized modern medicine by saving countless lives from bacterial infections. However, their widespread use has inadvertently harmed the delicate balance of the human gut microbiota. The gut microbiota, a complex community of bacteria, archaea, viruses, and fungi, plays a vital role in regulating metabolism, immune responses, and maintaining intestinal health. Antibiotics, especially broad-spectrum types, disrupt this ecosystem by eradicating both harmful and beneficial...
Dysbiosis of the Gut Microbiota01:18

Dysbiosis of the Gut Microbiota

The human gut microbiome includes a diverse array of microbial species, including beneficial commensals and opportunistic pathogens, which interact to support host health. These microbes contribute to essential functions such as nutrient metabolism, immune system modulation, and maintenance of intestinal barrier integrity. However, disruptions to this equilibrium—referred to as dysbiosis—can have widespread physiological consequences.Dysbiosis is often characterized by reduced microbial...
Probiotics01:22

Probiotics

Probiotics are live, non-pathogenic microorganisms that confer health benefits by modulating the gut microbiota. The human gastrointestinal tract harbors a complex microbial ecosystem, and the balance of this microbiota is crucial for digestive and systemic health. Among the most extensively studied and utilized probiotics are species formerly classified within the genera Lactobacillus and Bifidobacterium. These organisms not only naturally colonize the human gut but are also consumed through...
Microbiota of the Large Intestine01:27

Microbiota of the Large Intestine

The large intestine hosts the most densely populated microbial ecosystem in the human body. This complex community primarily consists of anaerobic bacteria, with Bacillota (formerly Firmicutes) and Bacteroidota (formerly Bacteroidetes) as the predominant groups. The distribution of these microbes varies along different sections of the large intestine, influenced by local environmental factors such as oxygen availability and nutrient composition.The cecum, located at the beginning of the large...
Microbiota of the Stomach and Small Intestine01:27

Microbiota of the Stomach and Small Intestine

The human gastrointestinal (GI) tract is characterized by distinct physicochemical conditions that shape its microbial communities. Among these, the stomach presents a particularly challenging environment for microbial colonization due to its highly acidic pH, ranging from 1 to 3. This extreme acidity effectively limits microbial density. However, certain acid-tolerant microorganisms are capable of surviving in this niche. Notably, Helicobacter pylori can colonize the gastric mucosa,...
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...

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Related Experiment Video

Updated: May 28, 2026

Evaluating Cell Death Using Cell-Free Supernatant of Probiotics in Three-Dimensional Spheroid Cultures of Colorectal Cancer Cells
06:07

Evaluating Cell Death Using Cell-Free Supernatant of Probiotics in Three-Dimensional Spheroid Cultures of Colorectal Cancer Cells

Published on: June 13, 2020

Synbiotics as a Microbiome-Based Strategy in Colorectal Cancer.

Lucia Maria Procopciuc1, Adrina Corina Hangan2, Roxana Liana Lucaciu3

  • 1Department of Medical Biochemistry, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania.

Nutrients
|May 27, 2026
PubMed
Summary
This summary is machine-generated.

Synbiotics, combining probiotics and prebiotics, show potential in managing colorectal cancer (CRC) by improving gut health and reducing tumor progression. Further research is needed to confirm their benefits in clinical settings.

Keywords:
colorectal cancermicrobiomesynbiotics

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A Method to Define the Effects of Environmental Enrichment on Colon Microbiome Biodiversity in a Mouse Colon Tumor Model
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A Method to Define the Effects of Environmental Enrichment on Colon Microbiome Biodiversity in a Mouse Colon Tumor Model

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Last Updated: May 28, 2026

Evaluating Cell Death Using Cell-Free Supernatant of Probiotics in Three-Dimensional Spheroid Cultures of Colorectal Cancer Cells
06:07

Evaluating Cell Death Using Cell-Free Supernatant of Probiotics in Three-Dimensional Spheroid Cultures of Colorectal Cancer Cells

Published on: June 13, 2020

A Method to Define the Effects of Environmental Enrichment on Colon Microbiome Biodiversity in a Mouse Colon Tumor Model
08:14

A Method to Define the Effects of Environmental Enrichment on Colon Microbiome Biodiversity in a Mouse Colon Tumor Model

Published on: February 28, 2018

Area of Science:

  • Gastroenterology and Oncology
  • Microbiome Research
  • Immunology

Background:

  • Colorectal cancer (CRC) involves complex interactions between gut microbiota, inflammation, and host signaling.
  • Synbiotics (probiotics + prebiotics) are emerging as potential therapeutic modulators in CRC.

Purpose of the Study:

  • To review the mechanisms of synbiotics in influencing colorectal cancer (CRC) development and progression.
  • To integrate preclinical and clinical data on synbiotic efficacy in CRC management.

Main Methods:

  • Literature review integrating preclinical and clinical studies on synbiotics and CRC.
  • Analysis of synbiotic effects on microbial balance, SCFAs, intestinal barrier, and inflammatory pathways.
  • Examination of impacts on molecular pathways like Wnt/β-catenin, NF-κB, and PI3K/Akt/mTOR.

Main Results:

  • Synbiotics restore microbial balance, enhance SCFAs, strengthen intestinal barrier, and reduce inflammation and oxidative stress.
  • Preclinical studies show synbiotics reduce tumor growth, increase apoptosis, and modulate the tumor microenvironment.
  • Clinical data suggest synbiotics may improve postoperative outcomes and reduce chemotherapy toxicity, though results are heterogeneous.

Conclusions:

  • Synbiotics demonstrate anti-tumor effects and modulate key molecular pathways involved in CRC.
  • Synbiotics represent a promising adjunctive strategy for colorectal cancer management, potentially enhancing therapeutic efficacy.
  • Further large-scale clinical studies are required to validate long-term benefits and establish standardized protocols for synbiotic interventions in CRC.