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Related Experiment Video

Updated: May 28, 2026

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

Circadian Modulation of Protein Catabolism: Insight from a Population Study.

Miriam Lisa Kafader¹, Sébastien Sare², Martina Zandonà²

¹Faculty of Biomedicine, Università della Svizzera Italiana, 6900 Lugano, Switzerland.

|May 27, 2026

Summary

Urinary urea excretion shows a nocturnal pattern, especially in older women. Age, blood pressure dipping, and sodium intake influence this circadian rhythm, offering insights for muscle health strategies.

Keywords:

ageing blood pressure dipping circadian rhythm nocturnal catabolism protein metabolism sex difference urinary urea excretion

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Measuring Diurnal Rhythms in Autophagic and Proteasomal Flux

Measuring Diurnal Rhythms in Autophagic and Proteasomal Flux

Published on: September 17, 2019

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Last Updated: May 28, 2026

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

Measuring Diurnal Rhythms in Autophagic and Proteasomal Flux

Measuring Diurnal Rhythms in Autophagic and Proteasomal Flux

Published on: September 17, 2019

Area of Science:

Chronobiology
Human Physiology
Nutritional Science

Background:

Urinary urea excretion indicates protein breakdown and follows daily rhythms.
Population-level patterns and drivers of urea excretion are not well understood.

Purpose of the Study:

To characterize the population-level diurnal pattern of urinary urea excretion.
To identify independent determinants of this pattern.

Main Methods:

Cross-sectional study of 859 adults from the Ticino Epidemiological Stiffness Study (TEST-study).
Calculation of a day-to-night (Day/Night) urinary urea excretion ratio from 24-hour urine collections.
Multivariable linear regression to identify determinants.

Main Results:

A predominant nocturnal urinary urea excretion pattern was observed (mean Day/Night ratio < 1).
Younger women (<40 years) showed an attenuated pattern, while older women (>65 years) had a more pronounced nocturnal excretion.
Advancing age, nocturnal blood pressure dipping, and higher sodium excretion were independently associated with the Day/Night urea ratio.

Conclusions:

Urinary urea excretion exhibits a significant Day/Night variation linked to age, sex, and hemodynamic factors.
Findings support chrononutritional strategies for preserving muscle health throughout life.