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Related Experiment Video

Updated: May 28, 2026

Human Skeletal Muscle Biopsy Procedures Using the Modified Bergström Technique

Human Skeletal Muscle Biopsy Procedures Using the Modified Bergström Technique

Published on: September 10, 2014

Astragalus membranaceus Modulates Inflammatory Markers Without Enhancing Muscle Function Following Intensified

Simone Villanova^1,2, Marco Gatti¹, Marta Colosio^1,3

¹Department of Molecular Medicine, University of Pavia, 27100 Pavia, Italy.

|May 27, 2026

Summary

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Inflammatory Response

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...

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Astragali radix supplementation did not enhance muscle strength during resistance training or prevent performance decline after intensified training. However, it did reduce exercise-induced increases in inflammatory markers tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6).

Area of Science:

Exercise Physiology
Nutritional Biochemistry
Immunology

Background:

Astragali radix is a traditional herb with antioxidant, anti-inflammatory, and immunomodulatory properties.
It is recognized for its potential in supporting post-exercise recovery.
The long-term effects of Astragali radix supplementation combined with resistance training remain unclear.

Purpose of the Study:

To investigate the effects of Astragali radix supplementation on muscle adaptation and recovery during resistance training.
To evaluate the impact of Astragali radix on inflammatory markers and muscle damage indicators following intensified training.

Main Methods:

A randomized controlled trial involving 24 moderately active participants.
Participants underwent 8 weeks of regular resistance training followed by 2 weeks of intensified training.

Keywords:

dietary supplementation inflammation muscle damage non-functional over-reaching

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Supplementation with Astragali radix or a placebo was administered throughout the study.

Main Results:

No significant differences in muscle strength (MVIT, 1RM) were observed between the Astragali radix and placebo groups during the resistance training phase.
Both groups experienced a decline in muscle strength after the intensified training period.
Astragali radix supplementation significantly attenuated the increase in tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) during the intensified training phase.

Conclusions:

Astragali radix supplementation did not provide additional benefits for muscle strength or prevent performance decrements during resistance and intensified training.
Astragali radix supplementation demonstrated an ability to mitigate increases in specific inflammatory markers (TNF-α, IL-6) during periods of intense exercise stress.