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MOF-Enabled Nanocellulose Composite Threads for Sustained Antibacterial Drug Delivery and Minimally Invasive
Meng Sun1,2, Meiyan Wu2, Ping Wang2
1College of Chemistry and Chemical Engineering, Qingdao University, Qingdao 266071, China.
Polymers
|May 27, 2026
Summary
Researchers developed a novel biodegradable antibacterial thread for facial rejuvenation. This nanocellulose/MOF composite thread offers sustained drug delivery, reducing infection risk and promoting tissue repair.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Regenerative Medicine
Background:
- Minimally invasive thread lifting is popular for facial rejuvenation but lacks antimicrobial properties, increasing infection risk.
- Current absorbable threads do not possess intrinsic antibacterial functionality, posing a challenge for postoperative safety.
Purpose of the Study:
- To develop a biodegradable, antibacterial lifting thread for soft tissue repositioning and facial rejuvenation.
- To create a multifunctional thread combining mechanical support, biodegradability, and sustained antibacterial activity.
Main Methods:
- Fabrication of a nanocellulose/MOF composite thread using carboxymethylated cellulose nanofibrils (CCNF) and sodium alginate (SA).
- Incorporation of tetracycline hydrochloride-loaded ZIF-8 nanoparticles for sustained antibacterial activity.
- Evaluation of thread morphology, tensile strength, drug release, antibacterial efficacy, biodegradability, cytocompatibility, and in vivo inflammatory response.
Main Results:
- The antibacterial CCNF/SA (AB-CCNF/SA) thread demonstrated a tensile strength of 80 MPa and uniform morphology.
- ZIF-8 nanoparticles facilitated controlled drug release, showing potent antibacterial activity against Staphylococcus aureus and Escherichia coli.
- The composite threads exhibited ~45% degradation in 56 days, >90% fibroblast viability, and comparable in vivo inflammatory responses to commercial collagen threads.
Conclusions:
- The developed nanocellulose/MOF composite thread offers a promising multifunctional platform for minimally invasive soft tissue lifting.
- This innovative thread integrates mechanical support, biodegradability, and sustained antibacterial properties, addressing limitations of current lifting threads.
- The strategy provides a versatile approach for biomedical implants requiring structural integrity and infection prevention.
