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Related Experiment Video

Updated: May 28, 2026

Fabrication of a Master Mold for Microneedles with a Micron-sized Air-vent Hole
06:25

Fabrication of a Master Mold for Microneedles with a Micron-sized Air-vent Hole

Published on: December 5, 2025

Development and Optimization of Polymer-Based Dissolving Microneedles Fabricated by Mold Casting Method.

Liubov Bodnar1, Tetiana Kovalova1, Volodymyr Yakovenko2

  • 1Drug Technology Department, Pharmaceutical Faculty, National University of Pharmacy, St. Hryhoriya Skovorody, 53, 61002 Kharkiv, Ukraine.

Polymers
|May 27, 2026
PubMed
Summary

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This study optimized dissolving microneedle systems for transdermal drug delivery by evaluating polymer blends. A 5% polyvinylpyrrolidone (PVP K-30) and 10% sodium alginate combination showed the best mechanical strength, penetration, and dissolution properties.

Area of Science:

  • Biomaterials Science
  • Pharmaceutical Technology
  • Drug Delivery Systems

Background:

  • Microneedle systems offer minimally invasive transdermal drug delivery.
  • Polymer matrix composition critically impacts microneedle performance.
  • Optimizing polymer blends is essential for effective dissolving microneedle fabrication.

Purpose of the Study:

  • To identify an optimal polymer composition for dissolving microneedle arrays.
  • To evaluate mechanical strength, dissolution, and penetration of various polymer systems.
  • To establish a base formulation for subsequent drug loading.

Main Methods:

  • Fabrication of microneedle matrices using polyvinylpyrrolidone (PVP K-30), methylcellulose, sodium alginate, and hyaluronic acid.
  • Evaluation of microneedle performance via in vitro dissolution, pH measurement, penetration studies (gelatin, Parafilm M), and mechanical compression testing.
Keywords:
3D printingmicroneedlesmold castingpolymer basetransdermal systems

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Dissolving Microneedle Array Patches Manufactured By Solvent Casting Technique and Essential Characterization of Microneedle-Based Biomedical Devices
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Dissolving Microneedle Array Patches Manufactured By Solvent Casting Technique and Essential Characterization of Microneedle-Based Biomedical Devices

Published on: January 30, 2026

Related Experiment Videos

Last Updated: May 28, 2026

Fabrication of a Master Mold for Microneedles with a Micron-sized Air-vent Hole
06:25

Fabrication of a Master Mold for Microneedles with a Micron-sized Air-vent Hole

Published on: December 5, 2025

Dissolving Microneedle Array Patches Manufactured By Solvent Casting Technique and Essential Characterization of Microneedle-Based Biomedical Devices
08:26

Dissolving Microneedle Array Patches Manufactured By Solvent Casting Technique and Essential Characterization of Microneedle-Based Biomedical Devices

Published on: January 30, 2026

  • Utilized 3D-printed and silicone molds for microneedle manufacturing.

    • Main Results:

    • Monopolymer systems exhibited trade-offs between strength and dissolution rate.
    • Combined polymer formulations demonstrated improved structural uniformity and balanced properties.
    • A formulation of 5% PVP K-30 and 10% sodium alginate achieved 96% penetration efficiency, 78% uniform dissolution, and an 8.5 min dissolution time.

    Conclusions:

    • Composite polymer matrices offer an optimal balance of mechanical stability, penetration, and dissolution rate for dissolving microneedles.
    • The 5% PVP K-30 and 10% sodium alginate formulation is highly promising for developing drug-loaded microneedle systems.
    • Hyaluronic acid addition enhanced structural uniformity and handling properties of the microneedles.