Transdermal Hormonal Therapy in Menopause: Current Evidence and Personalized Approaches.

Area of Science:

• Reproductive Endocrinology
• Women's Health
• Menopause Management

Background:

• Hormonal equilibrium is crucial for women's health, especially during menopause.
• Declining estrogen and progesterone impact vasomotor stability, bone, cardiovascular, cognitive, mood, and metabolic health.
• Menopausal symptoms can impair daily function and increase long-term health risks.

Purpose of the Study:

• To review the physiological basis, clinical indications, and evidence for transdermal menopausal hormone therapy.
• To highlight the expanding role of transdermal therapy in personalized menopausal care.
• To discuss its pharmacological profile, effectiveness, and emerging perspectives.

Main Methods:

• Review of current scientific literature on transdermal menopausal hormone therapy.
• Analysis of physiological effects, clinical indications, and evidence-based outcomes.
• Discussion of pharmacological profiles and comparative risks with oral formulations.

Main Results:

• Transdermal hormone therapy bypasses first-pass hepatic metabolism, leading to consistent serum hormone levels.
• This route may offer a lower risk of metabolic and thromboembolic complications compared to oral therapies.
• Growing recognition of its benefits in managing menopausal symptoms and improving women's health.

Conclusions:

• Transdermal menopausal hormone therapy is an increasingly important component of modern women's health management.
• It provides an effective and potentially safer alternative for hormonal replacement during and after menopause.
• Personalized, evidence-guided treatment strategies are essential for optimal menopausal care.