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Related Experiment Video

Updated: May 28, 2026

Evaluation of Respiratory System Mechanics in Mice using the Forced Oscillation Technique

Evaluation of Respiratory System Mechanics in Mice using the Forced Oscillation Technique

Published on: May 15, 2013

Vibrating Mesh and Jet Nebulizer Performance in Pediatric Respiratory Support: A Multi-Modality In Vitro Comparison.

Ronan MacLoughlin^1,2,3, Ann-Marie Crowe^4,5, Michael Scully⁵

¹Emerging Technologies, Aerogen Ltd., IDA Business Park, Dangan, H91 HE94 Galway, Ireland.

|May 27, 2026

Summary

Vibrating mesh nebulizers (VMN) significantly outperform jet nebulizers (JN) in delivering medication doses during pediatric ventilation. VMN offer faster delivery and less waste, crucial for effective aerosol therapy in children.

Keywords:

HFNT aerosol blow-by jet nebulizer mechanical ventilation pediatric vibrating mesh nebulizer

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Last Updated: May 28, 2026

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Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

Published on: April 6, 2017

Area of Science:

Respiratory Medicine
Biomedical Engineering
Pediatric Critical Care

Background:

Optimizing nebulized drug delivery is critical for pediatric respiratory support.
Comparing jet nebulizers (JN) and vibrating mesh nebulizers (VMN) is essential for evidence-based device selection.
In vitro assessment provides foundational data for aerosol therapy performance.

Purpose of the Study:

To compare the in vitro nebulized drug delivery of a vibrating mesh nebulizer (VMN) versus a jet nebulizer (JN).
To evaluate device performance across various pediatric invasive and non-invasive ventilation models.
To assess absolute inhaled dose, delivery rate, and residual volume for different delivery methods.

Main Methods:

Comparative in vitro study using a continuous output JN (Aquineb) and a VMN (Aerogen Solo A-VMN).
Utilized pediatric models for spontaneous breathing (9-month-old simulation) and mechanical ventilation (pediatric breathing circuit with ETT).
Assessed drug delivery via face mask, mechanical ventilation, high-flow nasal therapy, and blow-by methods, quantifying dose spectrophotometrically.

Main Results:

VMN delivered nearly double the dose compared to JN during spontaneous breathing (p < 0.001).
VMN showed over a 3-fold increase in delivered dose during mechanical ventilation (p < 0.0001).
VMN consistently provided faster delivery rates and lower residual volumes across all tested ventilation modalities.

Conclusions:

VMN demonstrate superior in vitro drug delivery performance compared to JN in pediatric ventilation models.
VMN offer enhanced dose delivery, faster rates, and reduced waste, supporting improved aerosol therapy.
These findings support evidence-based selection of nebulizer technology for pediatric patients requiring respiratory support.