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Published on: March 8, 2019
Intraocular Lens Modifications for Postoperative Complication Prevention: Advances in Surface Engineering, Drug
Meitong Lin1,2, Wenlu Yu1,2, Ke Zhang3
1State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Sun Yat-sen University, Guangzhou 510060, China.
Pharmaceutics
|May 27, 2026
Summary
Intraocular lens (IOL) modifications are crucial for preventing common post-surgery complications like posterior capsule opacification and endophthalmitis, enhancing long-term vision outcomes after cataract surgery.
Area of Science:
- Ophthalmology
- Materials Science
- Pharmacology
Background:
- Cataract surgery with intraocular lens (IOL) implantation is standard for reversible blindness.
- Postoperative complications, including posterior capsule opacification (PCO) and endophthalmitis, limit long-term efficacy.
- Effective prophylactic strategies are needed to mitigate these complications.
Purpose of the Study:
- To provide a comprehensive review of recent advancements in IOL modification for preventing postoperative complications.
- To critically evaluate different IOL modification strategies, including their mechanisms, advantages, and limitations.
- To offer insights for accelerating clinical translation of IOL modification technologies.
Main Methods:
- Categorization of recent IOL modifications into surface modification, drug delivery systems, and photo-responsive IOLs.
- Critical evaluation of the mechanisms, advantages, and limitations of each category.
- Review of combined modification strategies and multifunctional IOL systems.
Main Results:
- Surface modification aims to improve biocompatibility and reduce PCO.
- Drug delivery IOLs offer sustained release of therapeutic agents to prevent infection and inflammation.
- Photo-responsive IOLs provide controlled drug release or therapeutic effects triggered by light.
Conclusions:
- IOL modification is a promising approach to mitigate major postoperative complications.
- Interdisciplinary collaboration is driving innovation in multifunctional IOL systems.
- Strategic development is essential to bridge the gap between IOL modification research and clinical application.
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