Related Experiment Video
Updated: May 28, 2026

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model
Published on: June 6, 2025
Plant Extracts Downregulating the JAK/STAT Signaling Pathway as a Potential Tool for Psoriasis Management: A Review
Maria Rosaria Perri1, Giulia Conforti2, Eugenio Provenzano3
1Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy.
Plant extracts show promise in managing psoriasis by targeting the JAK/STAT signaling pathway. These natural compounds may offer an effective approach to downregulate inflammation in this chronic skin disease.
Area of Science:
- Dermatology
- Immunology
- Pharmacology
Background:
- Psoriasis is a disabling inflammatory skin disease.
- Its pathogenesis involves inflammatory signaling pathways, notably the JAK/STAT pathway.
Purpose of the Study:
- To review current research on plant extracts for psoriasis management.
- To investigate the modulation of the JAK/STAT signaling pathway by these extracts.
Main Methods:
- Literature review of in vitro and in vivo studies.
- Analysis of plant extracts and herbal formulations targeting the JAK/STAT pathway.
Main Results:
- Several plant species demonstrate efficacy in modulating JAK/STAT signaling in psoriasis.
- Both raw/enriched extracts and formulations showed potential benefits.
Conclusions:
- Plant-based products targeting the JAK/STAT pathway are promising for psoriasis.
- Further research can explore these natural interventions for effective psoriasis management.
Related Concept Videos
The JAK-STAT Signaling Pathway
Receptor Downregulation in MVBs
The EGFR can initiate signaling pathways that lead to cell proliferation, migration, and differentiation. Overexpression of EGFR stimulates cells to proliferate. Excessive EGFR activation may...
NF-κB-dependent Signaling Pathway
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
Interactions Between Signaling Pathways
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
MAPK Signaling Cascades