Related Experiment Video
Updated: May 28, 2026

System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis
Published on: April 5, 2017
Covalent Inhibitors Targeting Mycobacterial Enzymes: Current Status, Challenges and Future Perspectives
Mariana Luiza Silva1, Matteo Mori2, Stefania Villa2
1Laboratory for Synthesis of Medicinal Molecules (LaSMMed), Department of Chemistry, State University of Londrina, Rodovia Celso Garcia Cid (PR-445), Londrina 86057-970, Brazil.
Abstract:
This review offers a critical and comprehensive overview of the most promising covalent inhibitors against traditional and emerging enzymatic targets of Mycobacterium tuberculosis (Mtb). Nearly three decades after the World Health Organisation's (WHO) declaration of tuberculosis (TB) as a global health emergency, Mtb continues to claim millions of lives, remaining among the leading causes of death worldwide. In recent years, several efforts have been devoted to shortening and improving treatment outcomes and to overcoming increasing drug resistance. The aim of our work is to provide a perspective on recent progress in the field of covalent inhibitors of mycobacterial enzymes, highlighting the current landscape and outlining future directions for safer and more effective strategies.
Related Concept Videos
Inhibitors of Bacterial Protein Synthesis
Inhibitors of Bacterial DNA Synthesis
Microbial Corrosion
Clinical Significance of Antibiotic Resistance
Antimicrobial Effectiveness
Development of Antibiotic Resistance

