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Assessment of Ovarian Cancer Spheroid Attachment and Invasion of Mesothelial Cells in Real Time
Published on: May 20, 2014
Ovarian Mucinous Neoplasms Associated With Mesonephric-like Lesions: An Updated Study With Novel Pathologic Features
Colton Smith1, Jonathan Dudley1, Johanna Savage2
1Departments of Pathology.
The American Journal of Surgical Pathology
|May 27, 2026
Summary
This study explores rare co-occurrences of mesonephric-like lesions and ovarian mucinous tumors, revealing potential precursor roles for benign mesonephric-like proliferation (MLP) and hyperplasia (MLH) in developing mesonephric-like adenocarcinoma (MLA). Further research is needed on this unique biological process.
Area of Science:
- Gynecologic Pathology
- Oncology
- Molecular Pathology
Background:
- The co-occurrence of mesonephric-like proliferation (MLP), mesonephric-like hyperplasia (MLH), and mesonephric-like adenocarcinoma (MLA) with ovarian mucinous tumors is rare, with limited understanding of its pathology and biology.
- Previous reports are scarce, necessitating further investigation into this unique phenomenon.
Purpose of the Study:
- To report additional cases of mesonephric-like lesions coexisting with ovarian mucinous neoplasms.
- To provide expanded observations and novel pathologic features of these rare co-occurrences.
- To investigate the potential precursor relationship between benign mesonephric-like lesions and mesonephric-like adenocarcinoma.
Main Methods:
- Retrospective analysis of 9 cases with mesonephric-like lesions and ovarian mucinous tumors.
- Immunohistochemical staining for PAX8, GATA3, and TTF-1.
- Molecular analysis, including KRAS mutation testing and targeted gene sequencing (ARID1A, DNMT3A, PIK3CA, TET2).
Main Results:
- All mesonephric-like lesions were PAX8 positive; 7/9 were diffusely GATA3 positive. Focal TTF-1 expression was noted in 44.4% of cases.
- Mucinous tumors generally showed PAX8 positivity, except in one case.
- Molecular analysis in one case revealed a common KRAS mutation in all components, but lineage-specific mutations in other genes, suggesting clonal relatedness and distinct differentiation pathways.
Conclusions:
- The coexistence of benign MLP/MLH with MLA suggests a potential precursor role for MLP/MLH in the development of MLA.
- These coexisting lesions, documented in 20 cases to date, represent a unique biological process and a model for studying transdifferentiation and tumorigenesis.
- This study reports novel associations, including MLA with lower GI-type mucinous tumors, MLA with mucinous adenocarcinoma, and independent bilateral ovarian involvement by MLP/MLH and mucinous borderline tumor.
