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Updated: May 28, 2026

Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing

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Published on: August 14, 2019

Relationship between prostatic fluorodeoxyglucose uptake, prostatic calcifications, and urologic symptom

Jai Hyuen Lee¹, Jonghyuk Choi^2,3, Seokgun Park¹

¹Department of Nuclear Medicine, Dankook University College of Medicine, Cheonan, South Korea.

Nuclear Medicine Communications

|May 27, 2026

Summary

Fluorodeoxyglucose (FDG) PET/CT findings like prostate uptake and calcifications correlate with increased urinary symptoms and lower quality of life in men. This imaging may help evaluate chronic prostatitis/chronic pelvic pain syndrome.

Keywords:

National Institutes of Health Chronic Prostatitis Symptom Index prostatic calcification fluorodeoxyglucose PET/CT prostate-specific antigen the International Prostate Symptom Score

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Area of Science:

Urology
Nuclear Medicine
Radiology

Background:

Urological symptom questionnaires are crucial for assessing conditions like chronic prostatitis/chronic pelvic pain syndrome.
The role of incidental findings on fluorodeoxyglucose (FDG) Positron Emission Tomography/Computed Tomography (PET/CT) in relation to these symptoms is not fully understood.

Purpose of the Study:

To evaluate the clinical utility of FDG PET/CT in assessing urological symptom scores.
To explore the relationship between incidental prostate FDG uptake, prostatic calcifications (PCs), and urological symptoms.

Main Methods:

Men undergoing health screening with FDG PET/CT and completing urological symptom questionnaires were analyzed.
Univariate and multivariate logistic regression analyses, along with Spearman correlation, were used to assess associations between imaging findings and symptom scores, adjusting for clinical parameters.

Main Results:

Of 368 participants, 104 had prostate FDG uptake or calcifications.
Both FDG uptake and prostatic calcifications were significantly associated with higher scores on the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI), International Prostate Symptom Score (IPSS), and quality of life (QoL) measures.
Strong correlations were found between IPSS/QoL and total CPSI scores.

Conclusions:

Prostate FDG uptake and calcifications detected by FDG PET/CT are strongly linked to increased urological symptoms and diminished quality of life.
FDG PET/CT can offer valuable supplementary information for evaluating latent urinary tract symptoms and chronic prostatitis/chronic pelvic pain syndrome.