Related Experiment Video
Updated: May 28, 2026

Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers
Published on: October 28, 2015
Intramolecular Steric Congestion Tailored Excited-State Dynamics of C═C Photorotation for Effective Photothermal
Tong Zheng1, Youquan Yan1, Yunhe Zhang1
1Shandong Key Laboratory of Advanced Glass Manufacturing and Technology, School of Materials Science and Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan, China.
Abstract:
The design of high-performance organic photothermal agents (PTAs) is often impeded by a limited understanding of their photothermal conversion mechanisms. Herein, through combined theoretical calculations with experimental investigations, we demonstrate a precise strategy for tuning photothermal conversion efficiency (PTCE) in donor-acceptor (D-A) molecules (namely, AD-IO, AD-NIO, and AD-BIO) bridged by a photo-driven rotatable C═C bond. By introducing tailored intramolecular interactions, molecular steric congestion is systematically increased, leading to enhanced structural nonplanarity, which in turn governs the excited-state rotational dynamics around the pivotal C═C bond. Such controlled C═C photorotation significantly accelerates nonradiative excited-state decay through conical intersections (CIs) to the ground (S0) state, resulting in remarkably high PTCEs up to 69.9% under near-infrared (NIR) irradiation. Notably, nanoparticles loaded with the photothermal agent AD-BIO show superior NIR photothermal performance and excellent stability, enabling effective antibacterial applications. This work elevates intramolecular interaction manipulation into a general design paradigm for engineering excited-state energy dissipation, enabling high-performance PTAs with precisely tunable photothermal conversion for broad applications.
More Related Videos
13:17In Vitro and In Vivo Evaluation of Photocontrolled Biologically Active Compounds - Potential Drug Candidates for Cancer Photopharmacology
Published on: September 29, 2023
11:26Integrating a Triplet-triplet Annihilation Up-conversion System to Enhance Dye-sensitized Solar Cell Response to Sub-bandgap Light
Published on: September 12, 2014
Related Concept Videos
Photochemical Electrocyclic Reactions: Stereochemistry
Selection Rules: Photochemical Activation
Thermal Electrocyclic Reactions: Stereochemistry
Selection Rules: Thermal Activation
Conjugated systems containing an even number of π-electron pairs undergo a conrotatory ring closure. For example, thermal electrocyclization of (2E,4E)-2,4-hexadiene, a conjugated diene containing two π-electron pairs, gives trans-3,4-dimethylcyclobutene.
Cycloaddition Reactions: MO Requirements for Photochemical Activation
Thermal and Photochemical Electrocyclic Reactions: Overview
Cycloaddition Reactions: MO Requirements for Thermal Activation
[3,3] Sigmatropic Rearrangement of 1,5-Dienes: Cope Rearrangement