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A Tangled Tale: Type 2 Autoimmune Pancreatitis With a Sclerosing Twist
Khaled H Husain1, Rachael Hagen1, Bianca Thakkar1
1Department of Medicine, University of Connecticut, Farmington, CT.
None:
Autoimmune pancreatitis (AIP) is an uncommon immune-mediated condition that can mimic pancreatic cancer and present with obstructive jaundice. Type 2 AIP is IgG4-independent and commonly associated with inflammatory bowel disease. We describe a woman with Crohn's disease who presented with abdominal pain, jaundice, and cholestatic liver injury. Imaging showed pancreatic head enlargement and biliary strictures concerning for malignancy. Initial biopsy and serology were inconclusive with normal immunoglobulin subclass 4 levels. Endoscopic ultrasound demonstrated chronic pancreatic inflammation, and corticosteroid therapy led to marked improvement, supporting a diagnosis of type 2 AIP complicated by secondary sclerosing cholangitis and type 3c diabetes.
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Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
