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Adjunctive Diode Laser Therapy and Probiotic Lactobacillus Therapy in the Treatment of Periodontitis and Peri-Implant Disease
Published on: May 9, 2022
Smart Nanogel Systems for Periodontitis Management: A Review of Microenvironment-Targeted Therapies
Shuqi Sun1,2, Dongning He1,2, Jingyi Yang1,2
1School and Hospital of Stomatology, Shanxi Medical University, Taiyuan, 030001, People's Republic of China.
International Journal of Nanomedicine
|May 27, 2026
Summary
Responsive nanogels offer precise periodontitis treatment by adapting to the disease microenvironment. These advanced materials improve drug delivery, combat infection, reduce inflammation, and promote tissue regeneration for better outcomes.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Periodontology
Background:
- Periodontitis is a chronic inflammatory disease causing irreversible bone loss.
- Current treatments like debridement and antibiotics are insufficient for the complex disease microenvironment.
- Nanotechnology offers novel solutions for targeted periodontitis therapy.
Purpose of the Study:
- To provide a comprehensive review of responsive nanogels for periodontitis treatment.
- To summarize nanogel design principles and innovative strategies for periodontal applications.
- To discuss the mechanisms of infection, inflammation, and tissue remodeling regulation by nanogels.
Main Methods:
- Systematic literature analysis of recent publications on responsive nanogels.
- Summarization of material basis and design principles of nanogels.
- Discussion of regulatory mechanisms and recent advances in multifunctional nanogel systems.
Main Results:
- Responsive nanogels intelligently adapt to microenvironmental triggers (pH, ROS, MMPs, biofilms).
- Nanogels enable on-demand drug release, synergistic antibacterial effects, and enhanced tissue regeneration.
- Multifunctional nanogels offer precise and controlled therapeutic interventions for periodontitis.
Conclusions:
- Responsive nanogels are a promising platform for enhancing periodontitis treatment efficacy and specificity.
- Challenges in biosafety, reproducibility, scalability, and clinical translation require further investigation.
- Continued research is essential to facilitate the clinical application of nanogel-based periodontal therapies.
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