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Related Experiment Video

Updated: May 28, 2026

Establishment and Characterization of Patient-derived Gastric Organoids from Biopsies of Benign Gastric Body and Antral Epithelium

Establishment and Characterization of Patient-derived Gastric Organoids from Biopsies of Benign Gastric Body and Antral Epithelium

Published on: January 26, 2024

Foveolar-Type Gastric Adenoma With a Raspberry-Like Appearance That Underwent Dramatic Morphological Changes Within

Kohei Funasaka¹, Tadahiro Yokoyama¹, Noriyuki Horiguchi¹

¹Department of Gastroenterology and Hepatology, Fujita Health University, Toyoake, Aichi, Japan, fujita-hu.ac.jp.

Case Reports in Gastrointestinal Medicine

|May 27, 2026

Summary

Foveolar-type gastric adenomas with a raspberry appearance can rapidly change morphology. This case shows a lesion evolving from a hyperplastic-like polyp to gastric adenoma with high-grade dysplasia within eight months.

Keywords:

FGA-RA case report endoscopic mucosal resection foveolar-type gastric adenoma with a raspberry-like appearance raspberry-like lesion

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Area of Science:

Gastroenterology
Oncology

Background:

Foveolar-type gastric adenomas with a raspberry-like appearance are newly identified entities.
Their etiology and development mechanisms are currently unknown.

Purpose of the Study:

To report a case of foveolar-type gastric adenoma with rapid morphological changes.
To highlight the potential evolution from a hyperplastic-like polyp to adenoma.

Main Methods:

Esophagogastroduodenoscopy for polyp observation and biopsy.
Endoscopic mucosal resection (EMR) for tissue diagnosis.
Histopathological examination for definitive diagnosis.

Main Results:

A patient initially diagnosed with hyperplastic polyps developed a raspberry-like lesion.
The lesion evolved into foveolar-type gastric adenoma with high-grade dysplasia within eight months.
The patient was on long-term vonoprazan for reflux esophagitis, later switched to famotidine.

Conclusions:

This case demonstrates the rapid evolution of a gastric lesion from a hyperplastic-like polyp to foveolar-type gastric adenoma with high-grade dysplasia.
The findings underscore the importance of close monitoring for gastric lesions, especially those with unusual morphology.