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Related Experiment Video

Updated: May 28, 2026

An Experimental Paradigm for the Prediction of Post-Operative Pain (PPOP)
14:56

An Experimental Paradigm for the Prediction of Post-Operative Pain (PPOP)

Published on: January 27, 2010

CYP2D6 phenotype and post-surgical pain control with hydrocodone and oxycodone.

Christelle Lteif1, Rachel A Myers2, Erica N Elwood1

  • 1Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics and Precision Medicine, College of Pharmacy, University of Florida, Gainesville, FL, United States.

Frontiers in Pharmacology
|May 27, 2026
PubMed
Summary

CYP2D6 metabolizer status did not impact hydrocodone or oxycodone pain relief after surgery. Multimodal pain management may lessen the effects of pharmacogenetics on opioid response.

Keywords:
CYP2D6hydrocodoneoxycodonepain controlpost-surgery

Related Experiment Videos

Last Updated: May 28, 2026

An Experimental Paradigm for the Prediction of Post-Operative Pain (PPOP)
14:56

An Experimental Paradigm for the Prediction of Post-Operative Pain (PPOP)

Published on: January 27, 2010

Area of Science:

  • Pharmacogenetics
  • Pain Management
  • Drug Metabolism

Background:

  • Hydrocodone and oxycodone are common postoperative pain relievers metabolized by CYP2D6.
  • The influence of CYP2D6 metabolizer status on their effectiveness is unclear.
  • This study investigated CYP2D6 phenotype's impact on pain and opioid use.

Purpose of the Study:

  • To evaluate the association between CYP2D6 phenotype and postoperative pain intensity.
  • To assess the relationship between CYP2D6 phenotype and opioid consumption.
  • To determine if CYP2D6 genotype affects analgesic response to hydrocodone and oxycodone.

Main Methods:

  • Secondary analysis of the ADOPT PGx Acute Pain Trial.
  • Compared CYP2D6 poor (PM) and intermediate (IM) metabolizers to normal (NM) metabolizers.
  • Assessed opioid use and pain intensity, adjusting for covariates.

Main Results:

  • No significant association was found between CYP2D6 phenotype and hydrocodone or oxycodone consumption or pain intensity.
  • Similar results were observed in the tramadol positive control group.
  • Concomitant non-opioid analgesic use was high across all cohorts.

Conclusions:

  • CYP2D6 metabolizer status did not influence postoperative pain control or opioid use for hydrocodone, oxycodone, or tramadol.
  • Multimodal analgesic strategies may attenuate the pharmacogenetic effects of CYP2D6 on opioid response.
  • The clinical impact of CYP2D6 on these analgesics appears limited in multimodal settings.