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Published on: October 2, 2020
ABO Blood Types and Mortality in Patients Undergoing Hemodialysis
Masafumi Kurajoh1, Tetsuo Shoji1,2,3,4, Shinya Nakatani5
1Department of Metabolism, Endocrinology and Molecular Medicine, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.
Patients with blood type A undergoing hemodialysis showed lower risks for all-cause and cardiovascular mortality compared to blood type O. This suggests ABO blood type may influence mortality outcomes in hemodialysis patients.
Area of Science:
- Nephrology
- Hematology
- Epidemiology
Background:
- ABO blood types are linked to mortality in the general population.
- The association between ABO blood types and mortality in hemodialysis patients is not well-established.
Purpose of the Study:
- To investigate the relationship between ABO blood types and mortality (all-cause, cardiovascular, noncardiovascular) in patients undergoing hemodialysis.
Main Methods:
- A prospective cohort study of 1671 hemodialysis patients in Japan over 5 years.
- ABO blood type data collected from medical records.
- Mortality outcomes analyzed using multivariable Cox regression and Fine-Gray subdistribution models.
Main Results:
- Blood type A was associated with a significantly lower risk of all-cause mortality (HR: 0.780; P=0.034) compared to blood type O.
- Blood type A also showed a lower risk of cardiovascular mortality.
- No significant association was found between ABO blood type and noncardiovascular mortality.
Conclusions:
- ABO blood type A may be associated with reduced all-cause and cardiovascular mortality in hemodialysis patients.
- Further research is warranted to confirm these findings and explore underlying mechanisms.
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