Related Experiment Video
Updated: May 28, 2026

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
Published on: July 5, 2022
Clinical, Serologic, and Histologic Characteristics in Screen-Detected and Clinically Diagnosed Celiac Disease
Iida Ahonen1, Laura Kivelä1,2,3, Aku Paavola1
1Tampere Celiac Disease Research Center, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Background And Aims:
The benefits of celiac disease screening remain debatable. We compared baseline characteristics and treatment outcomes between screen-detected and clinically diagnosed celiac disease adults in a prospective study.
Methods:
Clinical, serologic, and histologic data and bone mineral density (BMD) were assessed in 214 patients at diagnosis and after 1 year on gluten-free diet (GFD). Validated questionnaires were used to elicit gastrointestinal symptoms (Gastrointestinal Symptoms Rating Scale) and quality of life (Psychological General Well-Being questionnaire).
Results:
Screen-detected patients (n = 102) were older (median, 54 vs 43 years; P = .005), more often men (50% vs 16%; P < .001), and had higher mean lumbar T-score (-0.8 vs -1.2 standard deviation; P = .011) and hemoglobin levels (140 vs 128 g/dL; P < .001) at diagnosis than clinically diagnosed patients (n = 112). The groups were comparable in transglutaminase 2 (24.5 vs 47.7 U/mL; P = .051) and endomysial (1:200 vs 1:200; P = .385) autoantibody levels and histology assessed by villous height/crypt depth ratio (0.3 vs 0.3; P = .964). Screen-detected patients had fewer gastrointestinal symptoms (Gastrointestinal Symptoms Rating Scale total score 1.9 vs 2.6; P < .001) and better quality of life (Psychological General Well-Being questionnaire total score 107 vs 98; P = .001). After 1 year, both groups showed similar GFD adherence (94% vs 95%; P = .000) and improvements in histology, BMD, and quality of life. Asymptomatic and symptomatic screen-detected patients were comparable in histologic findings at diagnosis, adherence to GFD, and improvements in symptoms and quality of life.
Conclusion:
Screen-detected celiac disease patients demonstrated less severe symptoms and BMD impairment at diagnosis but advanced histologic and serologic disease similar to those identified on clinical grounds. Adherence to GFD and treatment response were comparable between the groups.
More Related Videos
10:27Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
Published on: December 15, 2011
06:50A High-Throughput Electrochemiluminescence 7-Plex Assay Simultaneously Screening for Type 1 Diabetes and Multiple Autoimmune Diseases
Published on: May 29, 2020
Related Concept Videos
Serum Laboratory Studies, Stool Test, Breath Test
Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
Inflammatory Bowel Disease IV: Clinical Manifestations
Type I Diabetes III: Clinical Manifestations