[Research progress on neutrophil gelatinase-associated lipocalin and sepsis-induced organ dysfunction]

The severity of multiple organ dysfunction caused by sepsis is directly associated with prognosis. Research into its pathophysiological mechanisms and exploration of organ protection strategies are key to improving the success rate of sepsis treatment. Neutrophil gelatinase-associated lipocalin (NGAL) was initially identified as one of the biomarkers for acute kidney injury (AKI). Recent studies have shown that NGAL is expressed in activated neutrophils and multiple human organs and tissues. It is associated with the development of multiple organ dysfunction in sepsis and is regarded as a biomarker for prediction of sepsis prognosis and assessment of multiple organ dysfunction. This review systematically elaborates on the biological characteristics and cellular sources of NGAL, as well as its role in sepsis-induced multiple organ injury, aiming to provide reference for research on multiple organ dysfunction in sepsis.