Related Experiment Video
Updated: May 28, 2026

Animal Models of Depression - Chronic Despair Model (CDM)
Published on: September 23, 2021
The concept of Depression revised according to Freud and Lacan: a comparison with the modern psychiatric paradigm
1Department of Life Science, Health, and Health Professions, Link Campus University, 00165 Rome, Italy - École de Psychanalyse des Forums du Champ Lacanien-France, Paris, France.
Abstract:
This article compares two perspectives on depression: the modern psychiatric paradigm, which conceives of depression as an episodic nosographic entity with neurobiological underpinnings, sometimes accompanied by psychotic symptoms; and the Lacanian psychoanalytic framework, which understands depression as an affect secondary to a specific psychic structure and to the subject's relation to the Real. In Freud's work, depression may be endogenous (melancholia) or related to grief, whereas in Lacan's theory it may arise within any psychic structure (neurotic, perverse, or psychotic) and reflects a subjective renunciation of knowledge, carrying a fundamental ethical dimension. The paper discusses the clinical implications of Lacanian perspective: it is crucial to assess the possible presence of an underlying psychotic structure beyond the depressive affect, in order to prevent potential harm for the patients.
Related Concept Videos
Depression: Overview
Freud's Psychoanalytic Theory
Freud's concept of psychic determinism asserts that...
Freudian Psychology
Cognitive Therapy
Depressive Disorders: Etiology
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Diagnostic and Statistical Manual of Mental Disorders (DSM)

