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Updated: May 28, 2026

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

Acute otitis media in children: molecular genetics approach (rs1061581), clinical and micro-social predictors

Larysa Sydorchuk1, Oleksii Sakovets1,2, Andrii Sydorchuk1

  • 1Department of Family Medicine, Bukovinian State Medical University, Chernivtsi, Ukraine.

Acta Oto-Laryngologica
|May 27, 2026
PubMed

Insights

The A-allele of the heat-shock protein gene (HSP70-2) is linked to more severe acute otitis media (AOM) in children. Clinical and social factors also significantly predict AOM severity based on age.

Area of Science:

  • Pediatrics
  • Genetics
  • Otolaryngology

Background:

  • Acute otitis media (AOM) is a common childhood ENT diagnosis.
  • Understanding AOM predictors is crucial for effective management.

Purpose of the Study:

  • To identify clinical, anamnestic, and micro-social predictors of AOM in children.
  • To investigate the association between AOM and heat-shock protein gene (HSP70-2, rs1061581) polymorphism.

Main Methods:

  • Study included 95 children aged 7-18 with AOM.
  • HSP70-2 (rs1061581) gene genotyping performed using qPCR.
  • Risk factors for AOM were analyzed.

Main Results:

  • The A-allele of HSP70-2 (rs1061581) is associated with a 2.5-fold increased risk of severe AOM and purulent ear discharge.
  • Factors like rhinitis, adenoid hypertrophy, lower respiratory tract diseases, and early daycare attendance increase AOM risk.
  • Chronic streptococcus persistence and broncho-obstructive diseases elevate AOM risk in adolescents.

Conclusions:

  • Age-dependent clinical and social factors influence AOM severity in children.
  • The HSP70-2 A-allele (rs1061581) is a significant predictor of more severe AOM.
  • Identifying these predictors can aid in AOM prevention and treatment strategies.
Abstract

Keywords:
Acute otitis mediaHSP70-2 gene (rs1061581)childrenclinical predictorscohort studyheat shock proteininflammationrisk factorssocial factors

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