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Updated: May 28, 2026

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
Published on: February 6, 2020
Design and application of amino acid-derived aromatic scaffolds in supramolecular covalent and non-covalent systems
Adrianna Szmulewicz1,2, Grzegorz Markiewicz1,2, Artur R Stefankiewicz1,2
1Center for Advanced Technologies, Adam Mickiewicz University, Uniwersytetu Poznańskiego 10, Poznań 61-614, Poland. grzegorz.markiewicz@amu.edu.pl.
Abstract:
Amino acids represent versatile building blocks for the design of functional supramolecular architectures, combining inherent chirality with a rich palette of non-covalent interactions. In recent years, considerable effort has been devoted to integrating amino acid motifs into π-conjugated aromatic cores such as naphthalene diimides (NDIs), benzene-1,3,5-tricarboxamides (BTAs) and other synthetically accessible scaffolds. These systems exemplify the power of modular molecular design, where subtle variations in side chains or peptide fragments can precisely tune self-assembly pathways, supramolecular morphology and responsiveness to external stimuli. This feature article reviews the strategies and principles underlying the construction of amino acid-derived supramolecular assemblies, covering both non-covalent and dynamic covalent approaches.
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