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Reconstruct Human Retinoblastoma In Vitro
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Reconstruct Human Retinoblastoma In Vitro

Published on: October 11, 2022

Cavitary retinoblastoma: Clinical features and treatment outcomes

Nakul Verma1, Rohan Kapoor1, Vijitha S Vempuluru2

  • 1Anant Bajaj Retina Institute, Hyderabad, Telangana, India.

Indian Journal of Ophthalmology
|May 27, 2026
PubMed

Insights

Cavitary retinoblastoma (RB) in children shows a good initial response to chemotherapy, with most cases achieving local tumor control and excellent prognosis for globe salvage. This study analyzed clinical characteristics and treatment outcomes in 40 patients.

Area of Science:

  • Ophthalmology
  • Pediatric Oncology

Background:

  • Cavitary retinoblastoma (RB) is a specific subtype of RB characterized by internal cavities within the tumor.
  • Understanding its clinical presentation and treatment response is crucial for effective management in children.

Purpose of the Study:

  • To delineate the clinical characteristics of cavitary retinoblastoma.
  • To evaluate treatment outcomes and prognosis in pediatric patients diagnosed with cavitary RB.

Main Methods:

  • Retrospective analysis of pediatric patients diagnosed with cavitary retinoblastoma.
  • Data collected included patient demographics, presenting symptoms, tumor classification (ICRB), cavity type (primary/secondary), treatment modalities, and follow-up outcomes.

Main Results:

  • The study included 40 patients (43 eyes) with cavitary RB, with a mean age at diagnosis of 25 months.
  • Leukocoria and strabismus were the most common presenting symptoms. Most eyes (98%) received intravenous chemotherapy (IVC).
  • Despite recurrence in 23% of eyes post-IVC, all eyes achieved local tumor control at a mean follow-up of 31 months, with no systemic metastasis or death.

Conclusions:

  • Cavitary retinoblastoma, encompassing both primary and secondary types, demonstrates a favorable initial response to standard chemotherapy.
  • The overall prognosis for globe salvage in these cases is excellent, highlighting the efficacy of current treatment protocols.
Abstract

Keywords:
Cavitarycavityclinical featuresretinoblastomatreatment

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