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Related Experiment Video

Updated: May 28, 2026

Doppler Optical Coherence Tomography of Retinal Circulation
10:46

Doppler Optical Coherence Tomography of Retinal Circulation

Published on: September 18, 2012

Real-Time High-Resolution OCT for Imaging Retinal and Choroidal Blood Flow.

Alessandro Invernizzi1,2, Francesco Romano1,3, Federico Corvi1

  • 1Eye Clinic, Department of Biomedical and Clinical Sciences, Ospedale Luigi Sacco, University of Milan, Milan, Italy.

Investigative Ophthalmology & Visual Science
|May 27, 2026
PubMed
Summary

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This summary is machine-generated.

Real-time high-resolution optical coherence tomography (High-Res OCT) effectively visualizes moving particles in retinal and choroidal vessels, outperforming standard OCT. This advancement offers new insights into ocular vascular dynamics.

Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Biomedical Engineering

Background:

  • Assessing ocular vascular dynamics is crucial for diagnosing and managing various eye conditions.
  • Current imaging techniques have limitations in visualizing intravascular flow in real-time.

Purpose of the Study:

  • To evaluate the feasibility of real-time high-resolution optical coherence tomography (High-Res OCT) for visualizing intravascular moving particles.
  • To compare the performance of High-Res OCT with standard OCT in retinal and choroidal vessels.

Main Methods:

  • A cross-sectional study involving 20 healthy eyes and 4 patients with retinal vascular disorders.
  • Imaging was performed using a prototype High-Res OCT device and standard SPECTRALIS HRA+OCT.
  • Real-time B-scan movie acquisition with eye-tracking was utilized, followed by qualitative assessment of intravascular particle visualization and flow direction.

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Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography
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Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography

Published on: March 26, 2020

Related Experiment Videos

Last Updated: May 28, 2026

Doppler Optical Coherence Tomography of Retinal Circulation
10:46

Doppler Optical Coherence Tomography of Retinal Circulation

Published on: September 18, 2012

Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography
07:23

Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography

Published on: March 26, 2020

Main Results:

  • High-Res OCT showed significantly superior visualization of moving particles in arteries (80% vs. 50%) and veins (90% vs. 60%) compared to standard OCT.
  • High intergrader agreement (AC1, 0.82-0.89) was achieved with High-Res OCT.
  • Real-time High-Res OCT visualized dynamic flow patterns and intravascular motion in pathological eyes.

Conclusions:

  • Real-time High-Res OCT enables non-invasive visualization of intravascular moving particles in ocular vessels.
  • This technique improves flow detectability and offers novel qualitative insights into ocular vascular dynamics.
  • High-Res OCT holds potential for future quantitative and translational applications in ophthalmology.