Related Experiment Video
Updated: May 28, 2026
14:18
Dioscin Mediated IgA Nephropathy Alleviation by Inhibiting B Cell Activation In Vivo and Decreasing Galactose-Deficient IgA1 Production In Vitro
Published on: October 13, 2023
Deciphering the Underlying Mechanisms Linking Psoriasis and IgA Nephropathy.
Zijie Tang1,2, Jintong Wu1,2, Meihan Dong1,3
1Medical School of Chinese People's Liberation Army (PLA), Beijing, China.
Journal of Immunology Research
|May 27, 2026
Summary
Psoriasis patients, especially those with severe or joint involvement, have an increased risk of developing Immunoglobulin A nephropathy (IgAN). Shared genetics and inflammation link these autoimmune conditions, but more research and screening are needed.
Area of Science:
- Immunodermatology
- Nephrology
- Autoimmune Diseases
Background:
- Psoriasis is a chronic inflammatory disease with systemic effects, including kidney complications.
- Immunoglobulin A nephropathy (IgAN) is the most common autoimmune glomerular disease globally.
- Evidence suggests a link between psoriasis and IgAN, particularly in moderate-to-severe or psoriatic arthritis cases.
Purpose of the Study:
- To review and synthesize current evidence connecting psoriasis and IgAN.
- To identify shared genetic and immune pathways.
- To propose a framework for clinical screening and future research.
Main Methods:
- Review of epidemiological, genetic, and transcriptomic studies.
- Analysis of inflammatory pathways involved in IgA1 production and deposition.
- Synthesis of evidence linking psoriatic inflammation to aberrant IgA1 glycosylation.
Main Results:
- Mendelian randomization studies indicate a shared genetic basis between psoriasis and IgAN.
- Transcriptomic analyses reveal overlapping immune signatures.
- Psoriatic inflammation may drive galactose-deficient IgA1 (Gd-IgA1) production and glomerular deposition, connecting skin and kidney disease.
Conclusions:
- Aberrant IgA1 glycosylation and tonsillar immune activation are proposed as key links between psoriasis and IgAN.
- Knowledge gaps exist due to limited renal screening in psoriasis trials and population-specific data.
- Establishing dedicated registries and integrating urinary tests into trials are crucial for personalized management.
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