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Updated: May 28, 2026

Efficient Synthesis of All-Carbon Quaternary Centers via the Conjugate Addition of Functionalized Monoorganozinc Bromides
Published on: May 26, 2019
Carbocyclization-oximation of alkenes via boryl radical-mediated halogen atom transfer to access fluorinated
Miao Tian1, Qinghao Dong1, Ruirui Fu1
1School of Chemistry and Chemical Engineering, Yantai University, Yantai, 264005, P. R. China. mtian827@163.com.
Abstract:
Distinct from traditional Giese-type hydroalkylations of alkenes via boryl radical-mediated halogen-atom transfer (XAT), a novel tandem strategy enabled by the dual-role reagent tert-butyl nitrite (TBN) is reported herein for the cyclizative difunctionalization of alkenes, delivering valuable 4-(carbaldehyde oxime)-fluorinated quinolinones. The protocol operates under mild, metal- and photocatalyst-free conditions, featuring a broad substrate scope, good functional group compatibility, and scalability.
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