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Pseudo-Signet Ring Cells: Diagnostic Pitfalls-Insights from Case Reports
Lina Chen1,2, Lai Mun Wang3, Runjan Chetty2
1Anatomic Pathology, Precision Diagnostics and Therapeutics Program, Sunnybrook Health Sciences Centre, 2075 Bayview Ave, Room E420A, Toronto, ON M4N 3M5, Canada.
Reports (MDPI)
|May 27, 2026
Summary
Pseudo-signet ring cells mimic malignant cells in the GI tract, posing a diagnostic challenge. Careful evaluation is essential to prevent misdiagnosis and ensure appropriate patient care.
Area of Science:
- Gastroenterology
- Pathology
- Oncology
Background:
- Pseudo-signet ring cells exhibit morphology similar to malignant signet ring cells.
- These benign cells are found in the gastrointestinal and biliary tracts.
- Their resemblance to adenocarcinoma poses a diagnostic challenge.
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01:21Cell-surface Signaling
Hormones—or any molecule that binds to a receptor, known as a ligand—that are lipid-insoluble (water-soluble) are not able to diffuse across the cell membrane. In order to be able to affect a cell without entering it, these hormones bind to receptors on the cell membrane. When a first messenger, a hormone, binds to a receptor, a signal cascade is set off, causing second messengers, proteins inside the cell, to become activated, resulting in downstream effects.
02:03What is Cell Signaling?
Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate to respond to the environment.