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Prognostic Significance of SULF2 Expression in Surgically Resected Non-Small Cell Lung Cancer
Hakan Taban1, Murat Ozdede2, Orkun Akman3
1Medical Oncology Clinic, Medical Park Ankara Hospital, Ankara 06680, Turkey.
Medical Sciences (Basel, Switzerland)
|May 27, 2026
Summary
Sulfatase 2 (SULF2) is common in non-small cell lung cancer (NSCLC) but does not significantly impact survival after surgery. Higher SULF2 expression showed a trend toward poorer outcomes, but this was not statistically significant.
Area of Science:
- Oncology
- Molecular Biology
- Cancer Research
Background:
- Sulfatase 2 (SULF2) is an extracellular enzyme implicated in tumor progression across various cancers.
- Its prognostic role in surgically resected non-small cell lung cancer (NSCLC) requires further clarification.
Purpose of the Study:
- To investigate the prognostic significance of Sulfatase 2 (SULF2) expression in patients with surgically resected non-small cell lung cancer (NSCLC).
Main Methods:
- Immunohistochemistry was used to assess SULF2 expression in 83 NSCLC tumor specimens from patients who underwent curative surgery.
- Expression levels were quantified and categorized as low or high, with survival outcomes (OS, DFS) analyzed using Kaplan-Meier and Cox models.
Main Results:
- SULF2 expression was detected in 94% of tumors, with 51.8% showing high expression.
- No statistically significant differences in overall survival (OS) or disease-free survival (DFS) were observed between low and high SULF2 expression groups.
- Multivariate analysis confirmed that SULF2 expression was not an independent predictor of OS or DFS.
Conclusions:
- SULF2 is highly prevalent in surgically resected NSCLC.
- While higher SULF2 expression trended towards poorer survival, the association lacked statistical significance.
- SULF2 expression is not a significant independent prognostic marker in this patient cohort.
