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Cell-mediated Immune Responses

Cell-mediated Immune Responses

Kidney Transplant I: Introduction

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...

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Related Experiment Video

Updated: May 28, 2026

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

Unsupervised Immune Profiling Identifies Distinct Post-Transplant T-Cell Clusters Associated with Kidney Allograft

Lampros Vagiotas¹, Asimina Fylaktou², Ariadni Fouza¹

¹Department of Transplant Surgery, Center for Research and Innovation in Solid Organ Transplantation, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.

Medical Sciences (Basel, Switzerland)

|May 27, 2026

Summary

This summary is machine-generated.

Distinct T-cell profiles after kidney transplant are linked to early kidney graft function. Identifying these immune cell clusters may help predict transplant outcomes.

Keywords:

CD16/56+ T cells T cells graft function senescence unsupervised clustering

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Last Updated: May 28, 2026

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

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Published on: August 12, 2017

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Published on: April 19, 2017

An Immunological Model for Heterotopic Heart and Cardiac Muscle Cell Transplantation in Rats

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Published on: May 8, 2020

Area of Science:

Immunology
Transplantation Biology
Renal Medicine

Background:

Immune heterogeneity post-kidney transplant can impact allograft success.
The clinical significance of circulating T-cell phenotypes is not fully understood.

Purpose of the Study:

To identify T-cell clusters based on 12-month post-transplant data.
To investigate the relationship between these T-cell clusters and kidney graft function patterns within the first year.

Main Methods:

Flow cytometry analyzed T-cell subpopulations in 112 kidney transplant recipients at 12 months.
Unsupervised hierarchical clustering and principal component analysis were used for T-cell data.
Longitudinal graft function (eGFR, creatinine) was assessed using generalized estimating equation models.

Main Results:

Three distinct T-cell clusters emerged: CD8-skewed cytotoxic/senescent, innate-like cytotoxic, and CD4-dominant.
Older age and cytomegalovirus seropositivity were linked to the CD8-skewed cluster.
Differences in serum creatinine and graft function trajectories were observed across clusters, though some associations were attenuated.

Conclusions:

Unsupervised clustering identified specific T-cell profiles associated with early kidney graft function.
These findings suggest T-cell phenotypes may influence early transplant outcomes.
Further longitudinal and external validation is required.