Japanese Consensus Document on NexoBrid^®, a Burn Eschar Removal Agent

Area of Science:

• Burn Management
• Wound Care
• Enzymatic Debridement

Background:

• NexoBrid® (NXB) is an enzymatic debridement agent approved in Japan for burn treatment.
• Optimal use requires patient selection and proper technique, with existing guidelines not fully applicable to Japan.
• A Japan-specific consensus document was developed by burn experts.

Purpose of the Study:

• To establish practical guidance for NexoBrid® (NXB) use in Japan.
• To address the need for Japan-specific recommendations due to differences in available resources.
• To improve burn care quality by clarifying NXB efficacy, safety, and precautions.

Main Methods:

• A questionnaire-based survey using the Delphi method was employed.
• Expert consensus was defined as agreement by at least 80% of committee members.
• Twenty-seven statements were evaluated over two rounds by seven Japanese burn experts.

Main Results:

• Consensus was achieved for 21 of 27 statements (77.8%) after two rounds.
• Finalized statements cover indications, pain management, application timing, technique, post-application care, skin grafting, and scarring.
• The consensus document integrates Japanese and international perspectives.

Conclusions:

• The consensus document offers practical guidance for NXB use in Japanese burn treatment.
• It aims to enhance burn care quality by clarifying efficacy, safety, and precautions.
• Recommendations are intended for updates as clinical experience grows.