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Acquired Platelet Dysfunction with Eosinophilia: A Narrative Review.
1Paediatric Haematology and Oncology Centre, Hong Kong Sanatorium and Hospital, Hong Kong.
Pediatric Reports
|May 27, 2026
Summary
Acquired platelet dysfunction with eosinophilia (APDE) is now found globally, not just in Southeast Asia. Standard diagnostic criteria are needed for this bleeding disorder, which typically affects younger males and resolves spontaneously.
Area of Science:
- Hematology
- Bleeding Disorders
- Platelet Function
Background:
- Acquired platelet dysfunction with eosinophilia (APDE) is a transient bleeding disorder.
- APDE was initially believed to be exclusive to Southeast Asia.
- Current diagnostic criteria and clinical features are not well-defined.
Purpose of the Study:
- To explore patient demography, epidemiology, diagnostic criteria, and laboratory findings of APDE.
- To review existing literature on APDE.
- To define the evolving characteristics of APDE.
Main Methods:
- A comprehensive literature search was conducted using MEDLINE, EMBASE, and Google Scholar.
- Included retrospective observational studies, case series, and case reports.
- Analyzed data from 431 patients.
Main Results:
- APDE cases are increasingly reported outside Southeast Asia.
- Male patients predominated (62.3%), with a median age in childhood/adolescence.
- Eosinophilia was absent in some cases, and thrombocytopenia occurred in 9.7%.
Conclusions:
- APDE is no longer geographically restricted to Southeast Asia.
- There is a need for uniform diagnostic criteria for APDE.
- Clinician awareness and accessible lab tests, like blood smear screening and platelet aggregometry, are crucial for diagnosis.
Keywords:
acquired platelet dysfunction with eosinophiliablood platelet disorderseosinophiliagrey platelet syndromeidiopathic purpura with grey plateletsthrombocytopeniaMore Related Videos
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