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Updated: May 28, 2026
Biological Compatibility Profile on Biomaterials for Bone Regeneration
Published on: November 16, 2018
Effect of combination of osteoblasts and octacalcium phosphate collagen composite on bone regeneration in rat
Hiroshi Kato1, Satoki Nishimura2, Shoko Onodera3
1Department of Oral and Maxillofacial Surgery, Tokyo Dental College, 2-9-18 Kanda Misakicho, Chiyoda-Ku, Tokyo, 100-0061, Japan. katohiroshi@tdc.ac.jp.
Abstract:
This study aimed to assess the effect of a combination of osteoblasts and octacalcium phosphate collagen composite (OCP/Col) on bone regeneration. In oral and maxillofacial surgery, OCP/Col has been clinically used as artificial bone. Although OCP/Col was reported to promote osteoblast differentiation, few studies have reported on its use in combination with cell transplantation. Moreover, its effects are not fully clarified. Therefore, we evaluated the osteogenic properties of a combination of OCP/Col and osteoblasts. We found that osteoblasts cultured in OCP/Col differentiated toward osteolineage, expressing several osteoblast markers. In animal experiments, the cell transplantation group showed promotion of osteoblast differentiation and stromal formation in the tissues compared with the OCP/Col group. These findings indicate that combining osteoblasts and OCP/Col would be beneficial for bone regeneration therapy.
