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Peptides from the Shadows: Molecular Depth Insights and Clinical Horizons of Circular RNA-encoded Peptides in Gliomas
Mokhtar Rejili1, Najma Farahani2, Mina Alimohammadi3,4
1Department of Biology, College of Sciences, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11623, Saudi Arabia.
Abstract:
Emerging evidence indicates that circular RNAs (circRNAs) can encode functional peptides, which participate in the regulation of both physiological and pathological processes. CircRNA-derived peptides are involved in the regulation of various cellular functions and signaling pathways by interacting with specific biological molecules. These peptides can influence tumor progression by modulating key signaling pathways and by promoting or inhibiting malignant phenotypes through defined mechanisms. Consequently, the suppression of particular circRNA-encoded peptides may contribute to the inhibition of glioma progression or facilitate tumor elimination. Given that the expression of certain circRNAs is elevated in glioma tissues and associated cells, they hold potential as diagnostic biomarkers and therapeutic targets. This review provides a comprehensive overview of circRNA-encoded peptides, focusing on their regulatory roles and functional mechanisms in glioma. We discuss how these small peptides contribute to glioma pathophysiology and consider their prospective applications in diagnosis, prognosis, and targeted therapy.
Insights
Circular RNAs (circRNAs) encode functional peptides that regulate cellular functions and impact glioma progression. Targeting these circRNA-derived peptides offers potential for glioma diagnosis and therapy.
Area of Science:
- Molecular Biology
- Oncology
- Biochemistry
Background:
- Circular RNAs (circRNAs) are increasingly recognized for their ability to encode functional peptides.
- These circRNA-derived peptides play roles in regulating physiological and pathological processes, including cellular functions and signaling pathways.
- Their involvement in tumor progression, particularly in glioma, is an area of active investigation.
Purpose of the Study:
- To provide a comprehensive overview of circRNA-encoded peptides in glioma.
- To elucidate their regulatory roles and functional mechanisms in glioma pathophysiology.
- To explore their potential as diagnostic biomarkers and therapeutic targets for glioma.
Main Methods:
- Literature review of studies on circRNA-encoded peptides in glioma.
- Analysis of molecular mechanisms by which these peptides influence tumor progression.
- Evaluation of the diagnostic and therapeutic potential of circRNA-derived peptides.
Main Results:
- CircRNA-derived peptides modulate key signaling pathways involved in glioma.
- These peptides can promote or inhibit malignant phenotypes through specific mechanisms.
- Elevated expression of certain circRNAs in glioma tissues suggests their utility.
Conclusions:
- CircRNA-encoded peptides are significant contributors to glioma pathophysiology.
- Suppression of specific circRNA-derived peptides may inhibit glioma progression or aid tumor elimination.
- CircRNAs and their encoded peptides represent promising targets for glioma diagnosis and therapy.
