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Related Experiment Video

Updated: May 28, 2026

The Microfluidic Probe: Operation and Use for Localized Surface Processing
08:07

The Microfluidic Probe: Operation and Use for Localized Surface Processing

Published on: June 4, 2009

Modular microfluidic probe for addressable fluidic landscapes.

Ayoub Glia1,2, Muhammedin Deliorman1, Mohammad A Qasaimeh1,2,3,4,5

  • 1Engineering Division, New York University Abu Dhabi, Abu Dhabi, United Arab Emirates. mohammad.qasaimeh@nyu.edu.

Lab on a Chip
|May 27, 2026
PubMed
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This study introduces a modular, 3D-printed framework for reconfigurable open-space microfluidics. The system enables precise chemical delivery on surfaces, overcoming limitations of traditional microfluidic devices.

Area of Science:

  • Microfluidics
  • Chemical Engineering
  • Biotechnology

Background:

  • Conventional microfluidic systems have fixed architectures, limiting adaptability and scalability for surface-based chemical delivery.
  • Precise, reconfigurable delivery of chemical cues on open surfaces is crucial for chemistry, biology, and diagnostics.

Purpose of the Study:

  • To develop a modular, 3D-printed framework for reconfigurable open-space microfluidics.
  • To enable plug-and-play reconfiguration of microfluidic functions without redesigning the entire system.

Main Methods:

  • Introduction of a 3D-printed input-processing-output-flow (IPOF) framework.
  • Utilizing interchangeable modules for controlled reagent delivery, flow confinement, mixing, and output node formation.
  • Demonstration of node-level operations including gradient discretization and multiplexed reagent delivery.

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Related Experiment Videos

Last Updated: May 28, 2026

The Microfluidic Probe: Operation and Use for Localized Surface Processing
08:07

The Microfluidic Probe: Operation and Use for Localized Surface Processing

Published on: June 4, 2009

Rapid Subtractive Patterning of Live Cell Layers with a Microfluidic Probe
12:19

Rapid Subtractive Patterning of Live Cell Layers with a Microfluidic Probe

Published on: September 15, 2016

A Modular Microfluidic Technology for Systematic Studies of Colloidal Semiconductor Nanocrystals
09:58

A Modular Microfluidic Technology for Systematic Studies of Colloidal Semiconductor Nanocrystals

Published on: May 10, 2018

Main Results:

  • The IPOF framework transforms continuous flows into discrete, addressable output nodes.
  • Achieved plug-and-play reconfiguration of open-space fluidic functions.
  • Enabled rapid system adaptation without cleanroom fabrication or full redesign.

Conclusions:

  • The modular IPOF architecture provides a scalable and accessible foundation for open-space microfluidics.
  • This approach supports emerging needs in high-content screening, precision bioanalysis, and translational research.
  • Decoupling fluidic function from fixed device geometry enhances system flexibility.