Related Experiment Video
Updated: May 29, 2026
08:18
Intracranial Pressure Monitoring In Nontraumatic Intraventricular Hemorrhage Rodent Model
Published on: February 8, 2022
Kidney Dysfunction-Associated Intracerebral Haemorrhage: Global Trends and Regional Disparities (1990-2021)
Lili Tang1,2, Hu Jiang3, Hongtao Zhang2
1The State Key Laboratory of Quality Research in Chinese Medicine, Faculty of Chinese Medicine, Macau University of Science and Technology, Macau, China.
Kidney & Blood Pressure Research
|May 27, 2026
Summary
The global burden of kidney dysfunction-associated intracerebral haemorrhage (KD-ICH) increased in absolute terms from 1990-2021, with significant health disparities. Targeted prevention and resource allocation are crucial to address this growing challenge.
Area of Science:
- Neurology
- Nephrology
- Global Health Epidemiology
Background:
- Kidney dysfunction is a growing risk factor for intracerebral haemorrhage (ICH).
- The global burden and trends of kidney dysfunction-associated ICH (KD-ICH) remain underexplored.
- Understanding KD-ICH burden is critical for public health interventions.
Purpose of the Study:
- To systematically evaluate the global burden, trends, health disparities, and future projections of KD-ICH from 1990 to 2021.
- To analyze KD-ICH impact across different demographic and socioeconomic strata.
- To inform targeted strategies for KD-ICH prevention and management.
Main Methods:
- Utilized data from the Global Burden of Disease Study 2021.
- Estimated deaths, DALYs, and age-standardized rates (ASMR, ASDR).
- Analyzed temporal trends (EAPC) and health inequalities (SII, concentration index), with future projections (ARIMA models).
Main Results:
- Absolute KD-ICH burden increased (deaths: 241,229 to 329,737; DALYs: 6.23M to 8.05M) despite declining age-standardized rates.
- Older adults (60-79) and males were disproportionately affected.
- Disparities were evident, with high burden concentration in low/middle-SDI regions and widening global inequities.
Conclusions:
- The rising absolute burden and significant health inequities of KD-ICH necessitate context-specific prevention.
- Improved chronic disease management and increased health system investment are vital.
- Equitable resource allocation is essential to mitigate future KD-ICH burden and address disparities.
Related Concept Videos
01:17Hemorrhagic Stroke l: Introduction
A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
01:22Acute Kidney Injury I: Introduction
Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
01:29Acute Kidney Injury II: Pathophysiology
Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
01:29Hemorrhagic Stroke ll: Pathophysiology
A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
01:29Acute Kidney Injury III: Clinical Manifestations
Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...