[EB 51 (Trivemil), a complete nutriment for parenteral alimentation]

Area of Science:

• Nutritional biochemistry
• Clinical nutrition
• Parenteral nutrition

Context:

• Parenteral nutrition requires simultaneous administration of amino acids and energy for optimal protein synthesis.
• Fat emulsions are crucial components of parenteral nutrition, providing essential fatty acids and calories.
• Evaluating novel formulations for improved patient outcomes in nutritional support is critical.

Purpose:

• To assess the efficacy and tolerance of EB 51 (Trivemil), a novel fat emulsion.
• To determine the suitability of EB 51 for providing amino acids and energy in patients requiring nutritional support.
• To evaluate nitrogen balance and lipid metabolism following administration of EB 51.

Summary:

• EB 51 is a fat emulsion containing L-amino acids, sorbitol, and wheat germ oil, providing 1000 kcal/L.
• Administered to 43 patients at 1000-1500 ml/day, EB 51 demonstrated excellent tolerance.
• Nitrogen balance studies and lipid blood tests indicated effective nitrogen utilization and good plasma clearing.

Impact:

• EB 51 shows promise as an effective component of parenteral nutrition, supporting anabolism.
• The formulation's excellent tolerance and beneficial metabolic effects suggest potential for improved patient outcomes.
• Further research into indications, dosage, and contraindications will refine its clinical application.