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Related Concept Videos

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Related Experiment Video

Updated: May 29, 2026

Opsono-Adherence Assay to Evaluate Functional Antibodies in Vaccine Development Against Bacillus anthracis and Other Encapsulated Pathogens
13:47

Opsono-Adherence Assay to Evaluate Functional Antibodies in Vaccine Development Against Bacillus anthracis and Other Encapsulated Pathogens

Published on: May 19, 2020

Active protein-capturing hydrogel for broad-spectrum pathogen defense.

Jiaming Liu1,2, Shiqi Hu1,2, Mengrui Liu1,2

  • 1Department of Biomedical Engineering, Columbia University, New York, NY, USA.

Science Advances
|May 27, 2026
PubMed
Summary
This summary is machine-generated.

An inhalable protein trap (IPT) is a new hydrogel that captures diverse proteins, including viral particles and allergens. This broad-spectrum protection effectively mitigates allergic and viral diseases.

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Photodegradable Hydrogel Interfaces for Bacteria Screening, Selection, and Isolation
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Published on: November 4, 2021

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Last Updated: May 29, 2026

Opsono-Adherence Assay to Evaluate Functional Antibodies in Vaccine Development Against Bacillus anthracis and Other Encapsulated Pathogens
13:47

Opsono-Adherence Assay to Evaluate Functional Antibodies in Vaccine Development Against Bacillus anthracis and Other Encapsulated Pathogens

Published on: May 19, 2020

Photodegradable Hydrogel Interfaces for Bacteria Screening, Selection, and Isolation
07:28

Photodegradable Hydrogel Interfaces for Bacteria Screening, Selection, and Isolation

Published on: November 4, 2021

Area of Science:

  • Biomaterials Science
  • Immunology
  • Infectious Disease

Background:

  • Proteinaceous agents like viruses and allergens are key drivers of infection and immune disorders.
  • Current methods for neutralizing these agents are limited in broad applicability and direct protein capture.
  • Mucosal surfaces are primary interfaces for pathogen entry and allergen exposure.

Purpose of the Study:

  • To develop and characterize an inhalable protein trap (IPT) for broad-spectrum neutralization of proteinaceous agents.
  • To evaluate the efficacy of IPT in capturing diverse biomolecules, including viral particles and allergens.
  • To assess the therapeutic potential of IPT in animal models of allergic and viral diseases.

Main Methods:

  • Development of an active hydrogel (IPT) utilizing NHS-amine chemistry for protein immobilization.
  • Structural optimization of IPT to ensure stability and functionality of reactive NHS esters under physiological conditions.
  • In vivo testing of IPT in animal models for allergic rhinitis, pollen-induced allergy, and viral infection.

Main Results:

  • IPT rapidly forms a hydrogel barrier upon hydration, covalently trapping proteins and proteinaceous particles within minutes.
  • The nonselective capture mechanism effectively binds viral particles, pollen/fungal allergens, and soluble mediators like histamine.
  • IPT demonstrated superior performance compared to commercial barrier sprays in blocking pathogenic proteins and reducing disease severity in animal models.

Conclusions:

  • IPT is a versatile platform for broad-spectrum protection against proteinaceous agents at biological interfaces.
  • The technology offers a novel approach for mitigating diseases driven by viral infections and allergic responses.
  • Further development of IPT holds promise for therapeutic applications in respiratory health.